Minyak Atsiri Kulit Jeruk Sebagai Bahan Obat Hirup Infeksi Saluran Pernapasan Akut (Ispa): Seleksi dan Organoleptik Prototipe Produknya

  • Nisa Lelita Fadilah IPB University
    (ID)
  • Mella Monica IPB University
    (ID)
  • Ria Heni Sigiro IPB University
    (ID)
  • Irmanida Batubara Institut Pertanian Bogor
    (ID)

Abstract

Acute Respiratory Infection (ARI) is an acute inflammation of the upper or lower respiratory tract caused by bacterial, viral, fungal and other parasitic infections. Lemon peels have been reported to contain beneficial compounds such as phenolic compounds and flavonoids. Flavonoids have been reported to have antioxidant, antibacterial, antiviral, anti-inflammatory, anti-allergic and anticancer activities. The review was conducted to select the orange peel from the best type of orange that can be used as an inhaler for people with ARI. National and international journals were selected based on the keywords citrus peel, antibacterial and antiviral. The chemical components reported in the essential oils of various citrus peels were determined and correlated with their related activity as antibacterial and antiviral. This systematic review shows that compounds that have the potential as antimicrobial, antibacterial and antiviral are flavonoids and limonina, these compounds are widely contained in the essential oil of lemon peel. The conclusion of the review shows that lemon peel essential oil has the potential as a raw material for anti-ARI drugs.

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References

Alfianur. 2017. Identifikasi komponen penyusun minyak atsiri kulit jeruk manis (Citrus sinensis L.) asal selorejo dan uji aktivitas antibakteri menggunakan metode kertas cakram [Skripsi]. Malang: Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Asgarpanah J, Motamed SM, Tomraee S. 2012. Volatile composition of the peel and leaf essensial oils of Citrus nobilis L. var deliciosa Swingle. African Journal of Biotechnology. 11(23): 6364-6367.

Astani A dan Schnitzler P. 2014. Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. Iranian Journal of Microbiology. 6(3): 149-155.

Bakkali F, Averbeck S, Averbeck D, Idaomar M. 2008. Biological effects of essential oils-A review. Food and Chemical Toxicology. 46(2008): 446–475.

Borusiewicza M, Trojanowskab D, Paluchowskab P, Janeczkoa Z, Petitjeanc MW, Budakb A. 2017. Cytostatic, cytotoxic, and antibacterial activities of essential oil isolated from Citrus hystrix. ScienceAsia. 43(2017): 96–106. doi:10.2306/scienceasia1513-1874.2017.43.096.

Cahyati S, Kurniasih Y, Khery Y. 2016. Efisiensi isolasi minyak atsiri dari kulit jeruk dengan metode destilasi air-uap ditinjau dari perbandingan bahan baku dan pelarut yang digunakan. Jurnal Ilmiah Pendidikan Kimia “Hydrogen”. 4(2): 103-110. ISSN 2338-6480.

Chalchat JC, Chiron F, Garry RPh, Lacoste J, Sautou V. 2000. Photochemical hydroperoxidation of terpenes. Antimicrobial activity of α- pinena, - pinena and limonina hydroperoxides. Journal of Essential Oil Research. 12(1): 125-134. doi: 10. 1080/10412905.2000.9712059.

Chi G, Wei M, Xie X, Soeomou L, Liu F, Zhao S. 2013. Suppression of MAPK and NF-kB pathways by limonina contributes to attenuation of lipopolysaccharide-induced inflamatory responses in acute lung injury. Inflammation. 36(2): 501-511.

Costa R, Bisignano C, Filocamo A, Grasso E, Occhiuto F, Spadaro F. 2014. Antimicrobial activity and chemical composition of Citrus aurantifolia (Christm.) swingle essential oil from Italian organic crops. Journal of Essential Oil Research. 26(6):400-408.

Dharmawan J, Kasapis S, Sriramula P, Lear MJ, Curran P. 2009. Evaluation of aroma-active compounds in pontianak orange peel oil (Citrus nobilis L. var. microcarpa hassk.) by gas chromatography-olfactometry, aroma reconstitution, and omission test. Journal of Agricultural and Food Chemistry. 57(1): 239-244.

Diao WR, Hu QP, Zhang H, Xu JG. 2014. Chemical composition, antibacterial activity and mechanism of action of essential oil from seeds of fennel (Foeniculum vulgare Mill.). Food Control. 35(1): 109–116.

Djabou N, Lorenzi V, Guinoiseau E, Andreani S, Giuliani MC, Desjobert JM, Bolla JM, Costa J, Berti L, Luciani A, Muselli A. 2013. Phytochemical composition of Corsican Teucrium essential oils and antibacterial activity against foodborne or toxi-infectious pathogens. Food Control. 30(1): 354–363. doi:10.1016/j.foodcont.2012.06.025.

Du Y, Luan J, Jiang R, Liu J, Ma Y. 2020. Myrcene exert anti-asthmatic activity in neonatal rats via modulating the matrix remodeling. International Journal Immunopathology and Pharmacology. 34(2020): 1-10. doi: 10.1177/2058738420954948.

Farahmandfar R, Tirgarian B, Dehghan B, Nemati A. 2019. Comparison of different drying methods on bitter orange (Citrus aurantium L.) peel waste: changes in physical (density and color) and essential oil (yield, composition, antioxidant and antibacterial) properties of powders. Journal of Food Measurement and Characterization. 14(2019): 862–875.

Fouad HA, Claudio AG, Camara D. 2017. Chemical composition and bioactivity of peel oils from Citrus aurantiifolia and Citrus reticulata and enantiomers of their major constituent against Sitophilus zeamais (Coleoptera: Curculionidae). Journal of Stored Products Research. 73(2017): 30-36. doi:10.1016/j.jspr.2017.06.001.

Fusvita A, Umar A. 2016. Identifikasi bakteri pernafasan penyebab infeksi saluran pernafasan (ISPA) pada usia balita di rumah sakit bahteramas. Jurnal Analis Kesehatan Kendari. 1(1):40-46.

Gursoy N, Tepe B, Sokmen M. 2010. Evaluation of the chemical composition and antioxidant activity of the peel oil of Citrus nobilis. International Journal of Food Properties. 13(5): 983–991. doi: 10.1080/10942910902927136

Hong JH, Khan N, Jamila N, Hong YS, Nho EY, Choi JY, Lee CM, Kim KS. 2017. Determination of volatile flavour profiles of Citrus spp. Fruits by SDE-GC-MS and enantiomeric composition of chiral coumpunds by MDGC-MS. Phytochemical Analysis. 28(5): 392-403. doi: 10.1002/pca.2686.

Hongratanaworakit T dan Buchbauer G. 2007. Chemical composition and stimulating effect of Citrus hystrix oil on humans. Journal of Flavour Frag. 22(2007): 443–449. doi: 10.1002/ffj.1820.

Hosni K, Zahed N, Chrif R, Abid I, Medfei W, Kallel M, Brahim NB, Sebei H. 2010. Composition of peel essential oils from four selected tunisian citrus species: evidence for the genotypic influence. Journal Food Chemistry. 123(2010): 1098–1104. doi:10.1016/j.foodchem.2010.05.068.

Irianto, Koes. 2014. Ilmu Kesehatan Anak. Bandung(ID): Alfabeta.

Islam A, Hellman B, Nyberg F, Amir N, Jayaraj R, Petroianu G, Adem A. 2020. Molecules. 25(19): 4492.

Kamal GM, Anwar F, Hussain AI, Sarri N, Ashraf MY. 2011. Yield and chemical composition of citrus essential oils as affected by drying pretreatment of peels. International Food Research Journal. 18(4): 1275-1282.

Kaskoos RA. 2019. Essential oil analysis by GC-MS and analgesic activity of Lippia citriodora and Citrus limon. Journal of Essential Oil Bearing Plants. 22(1): 273-281. doi: 10.1080/0972060X.2019.1603123.

Kong M, Chen XG, Liu CS, Liu CG, Meng XH, Yu LJ. 2008. Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli. Colloid Surfaces B-Biointerfaces. 65(2): 197–202. doi: 10.1016/j.colsurfb.2008.04.003

Mahalwal VS, Sanjrani MA. 2003. Volatile constituents of the fruits peels of Citrus lemon (Linn) Burm. F. Journal of Essential Oil bearing Plants. 6(1): 31-35.

Matuka T, Oyedeji O, Gondwe M, Oyedeji A. 2020. Chemical Composition and IN vivo Anti-inflammatory Activity of Essential Oils from Citrus sinensis (L.) osbeck Growing in South Africa. Journal of Essential Oil Bearing Plants. 23(4): 638-647. doi: 10.1080/0972060X.2020.1819885.

Moosavy MH, Hassanzeh P, Mohammadzadeh E, Mahmoudi R, Khatibi SA, Mardani K. 2017. Antioxidant and antimicrobial activities of essential oil of lemon (Citrus limon) peel in vitro and in a food model. Journal of Food Quality and Hazards Control. 4(2017): 42-48.

Nugraheni KS, Khasanah LU, Utami R, Ananditho BK. 2016. Pengaruh perlakuan pendahuluan dan variasi metode destilasi terhadap karakteristik mutu minyak atsiri daun kayu manis (C.Burmanii). Jurnal Teknologi Hasil Pertanian. 9(2): 51-64.

Njoroge SM, Mungai HN, Koaze H, Phi NTL, Sawamura M. 2006. Volatile constituents of mandarin (Citrus reticulata B.) peel oil from burundi. Journal of Essential Oil Research. 18(6): 659-662. doi:10.1080/10412905.2006.9699197.

Ontas C, Baba E, Kaplaner E, Kucukaydin S, Ozturk M, Ercan MD. 2016. Antibacterial activity of Citrus limon peel essential oil and Argania spinosa oil against fish pathogenic bacteria. Kafkas Univ Vet Fak Derg. 22(5): 741-749. doi: 10.9775/kvfd.2016.15311

Pathirana H, Wimalasema S, Silva B, Hossain S, Heo GJ. 2018. Antibacterial activity of lime (Citrus aurantifolia) essential oil and limonina againt fish pathogenic bacteria isolated from cultured olive flounder (Paralichthys olivaceus). Fisheries and Aquatic Life. 26(2018): 131-139. doi: 10.2478/aopf-2018-0014.

Paw M, Begum T, Gogoi R, Pandey SK, Lal M. 2020. Chemical composition of Citrus limon L. Burmnf peel essential oil from North East

India. Journal of Essential Oil Bearing Plants. 23(3):1-8.

Puspitasari FE. 2017. Pengaruh konsentrasi kulit jeruk lemon (Citrus limon) terhadap persepsi konsumen pada yoghurt susu kambing [Skripsi]. Yogyakarta: Universitas Sanata Dharma.

Quiroga P, Nepote V, Baumgartner M. 2019. Contribution of organic acids to a-terpinena antioxidant activity. Food Chemistry. 277(2019): 267-272. doi: 10.1016/j.foodchem.2018.10.100.

Shakeri A, Khakdan F, Soheili V, Sahebkar A, Rassam G, Asili J. 2014. Chemical composition, antibacterial activity, and cytotoxicity of essential oil from Nepeta ucrainica L. spp. kopetdaghensis. Industrial Crops and Products. 58(2014): 315–321. doi: 10.1016/j.indcrop.2014.04.009.

Sreepian A, Sreepian PM, Chanthong C, Mingkhwancheep T, Prathit P. 2019. Antibacterial activity of essential oil extracted from Citrus hystrix (kaffir lime) peels: an in vitro study. Tropical Biomedicine. 36(2): 531–541.

Tavallali H, Bahmanzadegan A, Rowshan V, Tavallali V. 2021. Essential oil composition, antioxidant activity, phenolic compounds, total phenolic and flavonoid contents from pomace of Citrus arantifolia. Journal of Medicinal Plants and By-products. 10(2021): 103-116.

Van Vuuren SF, Viljoen AM. 2007. Antimicrobial activity of limonene enantiomers and 1,8-cineole alone and in combination. Flavour and Fragrance Journal. 22(2007): 540–544. doi: 10.1002/ffj.1843.

Yanez C, Terrazas L, Estrada M, Campos J, Ortiz C, Hernandez L, Sanchez T, Farina G, Monroy, Martinez M. 2017. Anti-candida activity of bursera morelensis rmirez essential oil and two compunds, a-pinena and y-terpinena- an in vitro study. Molecules. 22(12): 1-13.

Yang F, Chen R, Li W, Zhu H, Chen X, Hou Z, Cao R, Zang G, Li Y, Zhang. 2021. D-limonina is a potential monoterpene to inhibit PI3K/Akt/IKK-a/NF-kB P65 Signaling Pathway in Coronavirus Disease 2019 Pulmonaru Fibrosis. Frontiers in Medicine. 8: 1-15.

Yang Z, Wu N, Zu Y, Fu Y. 2011. Comparative anti-infectious bronchitis virus (IBV) activity of (-)-pinena: Effect on Nucleocapsid (N) Protein. Journal Molecules. 16: 1044-1054. doi:10.3390/molecules16021044.

Yoshitomi K, Taniguchi S, Tanaka K, Uji Y, Akimitsu K, Gomi K. 2016. Rice terpene synthase 24 (OsTPS24) encodes a jasmonate-responsive monoterpene synthase that produces an antibacterial y-terpinena against rice pathogen. Journal of Plant Physiology. 191: 120-126.

Yulianti FY, Palupi NE, Agismanto D. 2016. Keragaman jeruk fungsional Indonesia berdasarkan karakter morfologis dan marka RAPD. Jurnal Agrobiogen. 12(2): 91-100.

Published
2021-12-31
How to Cite
Fadilah, N. L., Monica, M., Sigiro, R. H., & Batubara, I. (2021). Minyak Atsiri Kulit Jeruk Sebagai Bahan Obat Hirup Infeksi Saluran Pernapasan Akut (Ispa): Seleksi dan Organoleptik Prototipe Produknya. Al-Kimia, 9(2), 201-220. https://doi.org/10.24252/al-kimia.v9i2.23686
Section
Literature Studies
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