EVALUASI TEPAT PENGGUNAAN OBAT LINI PERTAMA DAN LINI KEDUA ANTIHIPERTENSI PADA PASIEN PREEKLAMPSIA: A LITERATUR REVIEW
Abstract
Pendahuluan. Preeklampsia adalah suatu kelainan pada kehamilan termasuk hipertensi yang dapat menyebabkan kematian bayi. Preeklampsia merupakan suatu penyebab dari kematian perinatal kehamilan dan banyak terjadi di seluruh dunia. Tujuan penelitian ini adalah untuk mencegah dan mengobati hipertensi pada ibu, memperpanjang kehamilan dengan aman untuk janin yang lebih dewasa, dan meminimalkan paparan janin terhadap obat-obatan yang memberikan efek merugikan serta untuk mengetahui apakah penggunaan obat antihipertensi sudah sesuai dengan guidline pengobatan antihipertensi pada pasien preeklampsia. Metode pada penelitian ini adalah PICO (Population, Intervention, Comparation, Outcome). Hasil pengkajian menunjukkan bahwa obat Antihipertensi sering kali diresepkan terhadap pasien preeklampsia yang tidak sesuai dengan kebutuhan pasien. Hal ini dapat dijadikan acuan bagi dokter dan apoteker dalam meresepkan obat. Kesimpulan dari ke 20 jurnal yang telah di analisis dapat diketahui bahwa tepat penggunaan obat antihipertensi untuk pasien preeklampsia dapat dicapai dengan obat antihipertensi yang sesuai seperti golongan CCbs (Calsium-Channel Blockers) dan Beta Blockers sebagai obat pilihan pertama dan obat pilihan kedua untuk hipertensi pada ibu hamil.
References
Abdelrahman, T. N., Youssry, M. A., Radwan, A. M., & Ahmed, A. 2019. “Impact of intravenous infusion of labetalol combined with magnesium sulfate versus hydralazine combined with magnesium sulfate on fetomaternal hemodynamics in severe preeclampsia”. Ain-Shams Journal of Anesthesiolog 11 (5).
Alavifard, S., Chase, R., Janoudi, G., & Chaumont, A. 2019. ”First-line antihypertensive treatment for severe hypertension in pregnancy : A systematic review and network meta-analysis. Pregnancy Hypertension”. 179–187. https://doi.org/10.1016/j.preghy.2019.09.019.
Amore, C. D., Trotta, F., Cas, R. Da, Zocchetti, C., Cocci, A., & Traversa, G. 2015. “Antihypertensive drug use during pregnancy : a population based study”. Annali dell'Istituto superiore di sanita 51(3):236-243. https://doi.org/10.4415/ANN.
Aoki, S., Mochimaru, A., Yamamoto, Y., Kurasawa, K., Takahashi, T., & Hirahara, F. 2015. “Pregnancy outcomes of women with coexisting systemic lupus erythematosus flare and preeclampsia”. Int J Womens Health 7595(3), 410–414. https://doi.org/10.3109/14397595.2014.979522.
Arias-hern, G., Vargas-de-le, C., Calzada-mendoza, C. C., & Ocharan-hern, E. 2020. “Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia : A Randomized , Single-Blind , Controlled Trial”. Int J Hypertens. doi: 10.1155/2020/5347918.
Clark, S. M., Dunn, H. E., & Hankins, G. D. V. 2015. “A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy”. Seminars in Perinatology. 1–8. https://doi.org/10.1053/j.semperi.2015.08.011.
Cleary, K. L., Siddiq, Z., Ananth, C. V, Wright, J. D., Too, G., Alton, M. E. D., & Friedman, A. M. 2018. “Use of Antihypertensive Medications During Delivery Hospitalizations Complicated by Preeclampsia”. AHA Journals 131(3), 441–450. https://doi.org/10.1097/AOG.0000000000002479.
Ding, J., Ding, J., Kang, Y., Fan, Y., & Chen, Q. 2017. “Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia”. Endocr Connect. 6(8). https://doi.org/10.1530/EC-17-0130.
Evaluation, C., Labetalol, I., Nifedipine, O., & Hypertension, S. 2017. “Comparative Evaluation of Efficacy & Safety of Intravenous Labetalol and Oral Nifedipine in Severe Hypertension of Pregnancy”. Journal of Medical Science and Clinical Research 05(03), 18941–18947.
Grze, G., Wo, Ł., Walukiewicz, M., Rogowicz, D., & Gilewski, W. 2019. “The importance and safety of calcium antagonists in the treatment of hypertens on in pregnant women”. 16(February), 85–88. https://doi.org/10.1016/j.preghy.2019.03.001.
Karemore, M. N., & Avari, J. G. 2019. “Journal of Drug Delivery Science and Technology In-situ gel of nifedipine for preeclampsia : Optimization , in-vitro and in-vivo evaluation”. Journal of Drug Delivery Science and Technology, 50(December 2018), 78–89. https://doi.org/10.1016/j.jddst.2019.01.025.
Kemenkes RI. 2011. “Modul Penggunaan Obat Rasional Dalam Praktek”. Modul Penggunaan Obat Rasional, 3–4. https://doi.org/10.1016/j.apergo.2015.07.007.
Magee, L. A., Group, S., Singer, J., Lee, T., Rey, E., & Ross, S. 2015. “Control of Hypertension In Pregnancy Study randomised controlled trial — are the results dependent on the choice of labetalol or methyldopa ?”. BJOG 1135–1141. https://doi.org/10.1111/1471-0528.13568.
Maternal Mortality. 2018. World Health Organitation (WHO).
Nader, A. M., Quinney, S. K., Fadda, H. M., & Foster, D. R. 2016. “Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs : a Case Study with Nifedipine”. The AAPS Journal, (11). https://doi.org/10.1208/s12248-016-9918-x.
Patel, R., Shah, R., Lad, D., Rana, D., & Malhotra, S. 2020. ”Comparative evaluation of efficacy and safety of methyldopa and labetalol in pregnancy ‑ induced hypertension : A meta ‑ analysis”. TJOG 6–9. https://doi.org/10.4103/TJOG.TJOG.
Shi, D., Wang, Y., Guo, J., Zhou, L., & Wang, N. 2017. “Vitamin D Enhances Efficacy of Oral Nifedipine in Treating Preeclampsia with Severe Features : A Double Blinded , Placebo-Controlled and Randomized Clinical Trial”. Front Pharmacol 8(865), 1–6. https://doi.org/10.3389/fphar.2017.00865.
Soerjono, S. 2017. Manajemen Farmasi : Lingkup Apotek Farmasi rumah sakit, Industri Farmasi, pedagang Besar Farmasi. Surabaya: Airlangga University Press.
Venkateswarlu, K., Reddy, T. R. M., Naveena, B., Reddy, E. S., & Prithi, A. 2020. “Evaluation of Safety and Efficay of Nifedipine in Pregnancy Induced Hypertension : A Prospective Observational Study”. International Journal of Public Health Researches & Develompent 11(01), 726–731.
Wang, Y., Liu, C., He, X., Li, Y., & Zou, Y. 2019. “Effects of metoprolol , methyldopa , and nifedipine on endothelial progenitor cells in patients with gestational hypertension and preeclampsia”. Clin Exp Pharmacol Physiol 46 (4) (302–312. https://doi.org/10.1111/1440-1681.13063.
Xiao, S., Zhang, M., Liang, Y., & Wang, D. 2017. “Short title : Celastrol against hypertension in preeclampsia”. Journal of the American Society of Hypertension. https://doi.org/10.1016/j.jash.2017.07.004.
Zhang, M. 2019. “Phytosterol enhances oral nifedipine treatment in pregnancy”. Biology and Medicine 244(13) 1120–1124. https://doi.org/10.1177/1535370219861574.
Copyright (c) 2021 Jurnal Midwifery
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Once an article was published in the journal, the author(s) are:
- granted to the journal right licensed under Creative Commons License Attribution that allows others to share the work with an acknowledgement of the work's authorship.
- permitted to publish their work online in third parties as it can lead to wider dissemination of the work.
- continue to be the copyright owner and allow the journal to publish the article with the CC BY-NC-SA license
- receiving a DOI (Digital Object Identifier) of the work.