Gender aspect of triglyceride, HDL, and their ratio in high school teachers in Makassar City, Indonesia
Abstract
Triglycerides, HDL, and their ratio are associated with metabolic disorders and diseases. Gender is known to have a relationship with these factors, but not consistent. This study wanted to see the relationship between gender and triglyceride levels, HDL levels, and the triglyceride / HDL ratio in secondary school teachers in Makassar City. The study was conducted with a cross-sectional approach in 6 junior high schools and 6 senior high schools with a total population of 200 teachers and involved 122 samples of teachers from secondary schools in Makassar City. Sampling using a stratified random sampling technique. The measurement of triglyceride and HDL levels was carried out by the Prodia laboratory. Data analysis was performed using the chi-square test. The results showed that there was a relationship between gender and triglyceride levels (p = 0.004). However, no relationship was found between HDL levels (p = 0.856) and the triglyceride / HDL ratio (p = 0.959) among secondary school teachers in Makassar City. Interventions to improve triglyceride levels must consider gender aspects primarily by paying more attention to male teachers.
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Alia, J. K., Jim, E. L., & Panda, A. L. (2020). Hubungan Rasio trigliserida/High Density Lipoprotein-Cholesterol (TG/HDL-C) dengan Kejadian Infark Miokard Akut di RSUP Prof. Dr. RD Kandou Manado. Medical Scope Journal, 1(2). https://doi.org/10.35790/msj.1.2.2020.27460
Baez-Duarte, B. G., Zamora-Gínez, I., González-Duarte, R., Torres-Rasgado, E., Ruiz-Vivanco, G., & Pérez-Fuentes, R. (2017). Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects. Gaceta médica de México, 153(2), 152-158. https://pubmed.ncbi.nlm.nih.gov/28474700/
Boehme, A. K., Esenwa, C., & Elkind, M. S. (2017). Stroke risk factors, genetics, and revention. Circulation research, 120(3), 472-495. https://doi.org/10.1161/CIRCRESAHA.116.308398
Boonchaya-anant, P., Laichuthai, N., Suwannasrisuk, P., Houngngam, N., Udomsawaengsup, S., & Snabboon, T. (2016). Changes in testosterone levels and sex hormone-binding globulin levels in extremely obese men after bariatric surgery. International journal of endocrinology, 2016. https://doi.org/10.1155/2016/1416503
Carlsson, A. C., Ärnlöv, J., Sundström, J., Michaëlsson, K., Byberg, L., & Lind, L. (2016). Physical activity, obesity and risk of cardiovascular disease in middle-aged men during a median of 30 years of follow-up. European journal of preventive cardiology, 23(4), 359-365. https://doi.org/10.1177/2047487314568034
Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism, 92, 6-10. https://doi.org/10.1016/j.metabol.2018.09.005
Chung, T. H., Shim, J. Y., Kwon, Y. J., & Lee, Y. J. (2019). High triglyceride to high‐density lipoprotein cholesterol ratio and arterial stiffness in postmenopausal Korean women. The Journal of Clinical Hypertension, 21(3), 399-404. https://doi.org/10.1111/jch.13484
Cundiff, D. K., & Agutter, P. S. (2016). Cardiovascular Disease Death Before Age 65 in 168 Countries Correlated Statistically with Biometrics, Socioeconomic Status, Tobacco, Gender, Exercise, Macronutrients, and Vitamin K. Cureus, 8(8), e748. https://doi.org/10.7759/cureus.748
Devi, K. S., Gupta, U., Dhall, M., & Kapoor, S. (2020). Incidence of obesity, adiposity and physical activity pattern as risk factor in adults of Delhi, India. Clinical Epidemiology and Global Health, 8(1), 8-12. https://doi.org/10.1016/j.cegh.2019.03.008
Dobiásová, M., & Frohlich, J. (2001). The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clinical biochemistry, 34(7), 583–588. https://doi.org/10.1016/s0009-9120(01)00263-6
Eeg-Olofsson, K., Gudbjörnsdottir, S., Eliasson, B., Zethelius, B., & Cederholm, J. (2014). The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: an observational study from the Swedish National Diabetes Register (NDR). Diabetes research and clinical practice, 106(1), 136-144. https://doi.org/10.1016/j.diabres.2014.07.010
Gasevic, D., Frohlich, J., Mancini, G. J., & Lear, S. A. (2014). Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study. Lipids in health and disease, 13, 159. https://doi.org/10.1186/1476-511X-13-159
Hallam, J., Boswell, R. G., DeVito, E. E., & Kober, H. (2016). Focus: sex and gender health: gender-related differences in food craving and obesity. The Yale journal of biology and medicine, 89(2), 161. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918881/
Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2020). Prevalence of obesity and severe obesity among adults : United States, 2017–2018 (N. C. for H. S. (U. S. ). D. of H. and N. E. Surveys. (ed.); Issue 360). https://stacks.cdc.gov/view/cdc/85451
He, F., Rodriguez-Colon, S., Fernandez-Mendoza, J., Vgontzas, A. N., Bixler, E. O., Berg, A., Imamura Kawasawa, Y., Sawyer, M. D., & Liao, D. (2015). Abdominal obesity and metabolic syndrome burden in adolescents--Penn State Children Cohort study. Journal of clinical densitometry: the official journal of the International Society for Clinical Densitometry, 18(1), 30–36. https://doi.org/10.1016/j.jocd.2014.07.009
Heart UK The Cholesterol Charity. (2014). High Density Lipoprotein (HDL). https://www.heartuk.org.uk/
Hussain, Z., Mehmood, S., Hussain, B., Ali, I., & Afzal, S. (2017). Prevalence of Obesity on Gender Base at Gilgit City, Pakistan. Adv Obes Weight Manag Control, 6(2), 00149. https://doi.org/10.15406/aowmc.2017.06.00149
Iwani, N. A. K. Z., Jalaludin, M. Y., Zin, R. M. W. M., Fuziah, M. Z., Hong, J. Y. H., Abqariyah, Y., ... & Nazaimoon, W. M. W. (2017). Triglyceride to HDL-C ratio is associated with insulin resistance in overweight and obese children. Scientific reports, 7(1), 1-7. https://doi.org/10.1038/srep40055
Kim, H. J., Park, H. A., Cho, Y. G., Kang, J. H., Kim, K. W., Kang, J. H., Kim, N. R., Chung, W. C., Kim, C. H., Whang, D. H., & Park, J. K. (2011). Gender Difference in the Level of HDL Cholesterol in Korean Adults. Korean journal of family medicine, 32(3), 173–181. https://doi.org/10.4082/kjfm.2011.32.3.173
Le-Ha, C., Beilin, L. J., Burrows, S., Huang, R. C., Oddy, W. H., Hands, B., & Mori, T. A. (2013). Gender difference in the relationship between passive smoking exposure and HDL-cholesterol levels in late adolescence. The Journal of clinical endocrinology and metabolism, 98(5), 2126–2135. https://doi.org/10.1210/jc.2013-1016
Lichtman, J. H., Leifheit, E. C., Safdar, B., Bao, H., Krumholz, H. M., Lorenze, N. P., Daneshvar, M., Spertus, J. A., D’Onofrio, G. (2018). Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction. Circulation, 137(8), 781–790. https://doi.org/10.1161/CIRCULATIONAHA.117.031650
Litwak, S. A., Wilson, J. L., Chen, W., Garcia-Rudaz, C., Khaksari, M., Cowley, M. A., & Enriori, P. J. (2014). Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice. Endocrinology, 155(11), 4447-4460. https://doi.org/10.1210/en.2014-1342
Mahbuba, S., Mohsin, F., Rahat, F., Nahar, J., Begum, T., & Nahar, N. (2018). Descriptive epidemiology of metabolic syndrome among obese adolescent population. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(3), 369-374. https://doi.org/10.1016/j.dsx.2017.12.026
Mahfouz, A. A., Shatoor, A. S., Khan, M. Y., Daffalla, A. A., Mostafa, O. A., & Hassanein, M. A. (2011). Nutrition, physical activity, and gender risks for adolescent obesity in Southwestern Saudi Arabia. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 17(5), 318–322. https://doi.org/10.4103/1319-3767.84486
Maki, K. C., Palacios, O. M., Lindner, E., Nieman, K. M., Bell, M., & Sorce, J. (2017). Replacement of refined starches and added sugars with egg protein and unsaturated fats increases insulin sensitivity and lowers triglycerides in overweight or obese adults with elevated triglycerides. The Journal of Nutrition, 147(7), 1267-1274. https://doi.org/10.3945/jn.117.248641
Mei, K., Huang, H., Xia, F., Hong, A., Chen, X., Zhang, C., ... & Yang, B. (2020). State‐of‐the‐art of measures of the obesogenic environment for children. Obesity Reviews. https://doi.org/10.1111/obr.13093
Negash, S., Agyemang, C., Matsha, T. E., Peer, N., Erasmus, R. T., & Kengne, A. P. (2017). Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study. BMC obesity, 4, 29. https://doi.org/10.1186/s40608-017-0165-1
Nurtazina, A., Kozhakhmetova, D., Dautov, D., Shakhanova, A., & Chattu, V. K. (2020). Apolipoprotein B/A1 Ratio as a Diagnostic Alternative to Triglycerides and HDL-Cholesterol for the Prediction of Metabolic Syndrome among Hypertensives in Kazakhstan. Diagnostics, 10(8), 510. https://doi.org/10.3390/diagnostics10080510
Taber, D. R., Robinson, W. R., Bleich, S. N., & Wang, Y. C. (2016). Deconstructing race and gender differences in adolescent obesity: Oaxaca-blinder decomposition. Obesity (Silver Spring, Md.), 24(3), 719–726. https://doi.org/10.1002/oby.21369
Trajkovska, K. T., & Topuzovska, S. (2017). High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol. Anatolian journal of cardiology, 18(2), 149. https://dx.doi.org/10.14744%2FAnatolJCardiol.2017.7608
Turek, L. V., Leite, N., Rodrigues Souza, R. L., Lima, J. K., Milano, G. E., Timossi, L., Osiecki, A. C., Osiecki, R., & Alle, L. F. (2014). Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels. Genetics and molecular biology, 37(3), 490–495. https://doi.org/10.1590/s1415-47572014000400003
Widyatmojo, H., Samsuria, I. K., & Triwardhani, R. (2019). Hubungan Kadar HbA1c Dan Rasio TG/HDL Dengan Cystatin-C Serum Pada Pasien Diabetes Melitus Tipe 2. Medica Hospitalia: Journal of Clinical Medicine, 6(2), 86-91. https://doi.org/10.36408/mhjcm.v6i2.388
Wu, H., Xiong, L., Xu, Q., Wu, J., Huang, R., Guo, Q., Mao, H., Yu, X., & Yang, X. (2015). Higher serum triglyceride to high-density lipoprotein cholesterol ratio was associated with increased cardiovascular mortality in female patients on peritoneal dialysis. Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(8), 749–755. https://doi.org/10.1016/j.numecd.2015.05.006
Yeom, H., Kim, H. C., Lee, J. M., Jeon, Y., & Suh, I. (2018). Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study. Lipids in health and disease, 17(1), 212. https://doi.org/10.1186/s12944-018-0861-y
Zhao, D., Guallar, E., Ouyang, P., Subramanya, V., Vaidya, D., Ndumele, C. E., Lima, J. A., Allison, M. A., Shah, S. J., Bertoni, A. G., Budoff, M. J., Post, W. S., & Budoff, M. J. (2018). Endogenous sex hormones and incident cardiovascular disease in post-menopausal women. Journal of the American College of Cardiology, 71(22), 2555-2566. http://doi.org/10.1016/j.jacc.2018.01.083
Zuhroiyyah, S. F., Sukandar, H., & Sastradinanja, S. B. (2017). Hubungan Aktivitas Fisik dengan Kadar Kolesterol Total, Kolesterol Low-Density Lipoprotein, dan Kolesterol High-Density Lipoprotein pada Masyarakat Jatinangor. Jurnal Sistem Kesehatan, 2(3). https://doi.org/10.24198/jsk.v2i3.11954
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