Percutaneous Coronary Intervention in Saphenous Vein Grafting Failure: A Case Report
Abstract
Bypass graft surgery for coronary arteries is an essential therapy for those diagnosed with multivessel arterial stenosis, particularly in patients with diabetes. Internal thoracic artery grafts are the most suitable choice for revascularizing severe arterial disease due to their durability and longevity. However, complete revascularization is challenging to achieve only with grafts from the artery, which means it requires using saphenous vein grafts (SVGs). Unfortunately, saphenous vein grafts lack the same level of structural integrity, and their malfunction is associated with substantial negative cardiac consequences and higher death rates. In this case, the patient is an 80-year-old male suffering from CABG surgery 13 years prior. He had cold sweats and frequent chest pain that shot up his back. Diabetes, hypertension, and smoking were among his risks. Electrocardiography showed significant ischaemia, and echocardiography indicated mild diastolic dysfunction and impaired left ventricular systolic function with a 48% ejection fraction. Laboratory results indicated increased troponin I production and random blood glucose. After percutaneous coronary intervention and DES implantation into the diagonal saphenous vein grafts, the patient was given beta-blockers, nitrates, and statins as dual antiplatelet treatment.
References
Weltert LP, Audisio K, Bellisaro A, et al. External stenting of vein grafts in coronary artery bypass grating: interim results from a two centers prospective study. Journal of Cardiothoracic Surgery. 2021;16(1):1-7. doi:10.1186/s13019-021-01406-0
Guida G, Ward AO, Bruno VD, et al. Saphenous vein graft disease, pathophysiology, prevention, and treatment. A review of the literature. Journal of Cardiac Surgery. 2020;35(6):1314-1321. doi:10.1111/jocs.14542
Back L, Ladwiniec A. Saphenous Vein Graft Failure: Current Challenges and a Review of the Contemporary Percutaneous Options for Management. Journal of Clinical Medicine. 2023;12(22):1-12. doi:10.3390/jcm12227118
Janiec M, Dimberg A, Lindblom RPF. Symptomatic late saphenous vein graft failure in coronary artery bypass surgery. Interdisciplinary CardioVascular and Thoracic Surgery. 2023;36(4):1-9. doi:10.1093/icvts/ivad052
Patted SV, Porwal SC, Ambar S, et al. Saphenous vein graft pci registry- a single centre experience. Indian Heart Journal. 2020;72:S15. doi:10.1016/j.ihj.2020.11.048
Karaaslan, Maden O, Kanal Y, et al. Association of CABG SYNTAX score with long term clinical outcomes in patients with acute myocardial infarction undergoing SVG PCI. European Review for Medical & Pharmacological Sciences. 2022;26(11):3893-3902. doi:10.26355/eurrev_202206_28957
Ren Y, Song B, Li J, et al. Underlying mechanisms of saphenous vein graft stenosis after coronary artery bypass caused by clipping of the side branches: an experimental study. Journal of Thoracic Disease. 2022;14(4):1088-1098. doi:10.21037/jtd-22-235
Lin L, Lu W, Wang X, et al. Short-term outcomes of drug-coated balloon versus drug-eluting stent for de novo saphenous vein graft lesions in coronary heart disease. Frontiers in Cardiovascular Medicine. 2023;10(March):1-8. doi:10.3389/fcvm.2023.982880
Xenogiannis I, Zenati M, Bhatt DL, et al. Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies. Circulation. 2021;144(9):728-745. doi:10.1161/CIRCULATIONAHA.120.052163
Ferrari G, Geijer H, Cao Y, Souza D, Samano N. Percutaneous coronary intervention in saphenous vein grafts after coronary artery bypass grafting: a systematic review and meta-analysis. Scandinavian Cardiovascular Journal. 2021;55(4):245-253. doi:10.1080/14017431.2021.1900598
Gharibeh L, Ferrari G, Ouimet M, Grau JB. Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting. Basic to Translational Science. 2021;6(4):388-396. doi:10.1016/j.jacbts.2020.11.015
Guida GA, Angelini GD. Pathophysiology and Mechanisms of Saphenous Vein Graft Failure. Brazilian journal of cardiovascular surgery. 2022;37(Special Issue 1):32-37. doi:10.21470/1678-9741-2022-0133
Medranda GA, Nathan S. Contemporary Saphenous Vein Graft Intervention: New Insights but Still More Questions. Journal of Society Cardiovascular Angiography & Interventions. 2024;(July):102282. doi:10.1016/j.jscai.2024.102282
Saidi-Seresht S, James S, Erlinge D, et al. Outcome of Saphenous Vein Graft Percutaneous Coronary Intervention Using Contemporary Drug-Eluting Stents: A SCAAR Report. Journal of Society Cardiovascular Angiography & Interventions. 2024;(June). doi:10.1016/j.jscai.2024.102232
Hall AB, Brilakis ES. Saphenous vein graft failure: seeing the bigger picture. Journal of thoracic disease. 2019;11(Suppl 9):S1441-S1444. doi: 10.21037/jtd.2019.03.09
Gemelli M, Addonizio M, Geatti V, Gallo M, Dixon LK, Slaughter MS, Gerosa G. Techniques and Technologies to Improve Vein Graft Patency in Coronary Surgery. Medical Sciences. 2024; 12(1):6. https://doi.org/10.3390/medsci12010006
Vervoort D, Malik A, Fremes SE. The evolving evidence base for coronary artery bypass grafting and arterial grafting in 2021: how to improve vein graft patency. JTCVS techniques. 2021 Dec 1;10:102-9. https://doi.org/10.1016/j.xjtc.2021.09.038
Copyright (c) 2025 Sidhi Laksono, A Tenri Syahirah

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Once an article was published in the journal, the author(s) are: granted to the journal right licensed under Creative Commons License Attribution that allows others to share the work with an acknowledgement of the work's authorship. permitted to publish their work online in third parties as it can lead wider dissemination of the work. continue to be the copyright owner and allow the journal to publish the article with the CC BY-NC-SA license receiving a DOI (Digital Object Identifier) of the work.