Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review

  • Haeria Doloking Universitas Hasanuddin Makassar
  • Subehan Lallo Universitas Hasanuddin Makassar
  • Marianti A Manggau Universitas Hasanuddin Makassar
  • Yusnita Rifai Universitas Hasanuddin Makassar
Keywords: Zerumbone, antioxidant, antiinflammation, oxidative stress, and narrative review


Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants.  Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.


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Author Biographies

Subehan Lallo, Universitas Hasanuddin Makassar



Marianti A Manggau, Universitas Hasanuddin Makassar



Yusnita Rifai, Universitas Hasanuddin Makassar




Abdelwahab, S. I., Abdul, A. B., Mohan, S., Taha, M. M. E., Syam, S., Ibrahim, M. Y., & Mariod, A. A. (2011). Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells. Leukemia Research, 35(2), 268–271.
Abdelwahab, S. I., Abdul, A. B., Zain, Z. N. M., & Hadi, A. H. A. (2012). Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells. International Immunopharmacology, 12(4), 594–602.
Ajish, K. R., Dhanya, B. P., Joseph, N., Rani, M. P., Raghu, K. G., Vineetha, V. P., & Radhakrishnan, K. V. (2014). Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction : a new class of a -glucosidase inhibitors. Tetrahedron Letters, 55(3), 665–670.
Akhtar, N. M. Y., Jantan, I., Arshad, L., & Haque, M. A. (2019). Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils. BMC Complementary and Alternative Medicine, 19(1), 331.
Al-Saffar, Ganabadi, S., Fakurazi, S., & Yaakub, H. (2011). Zerumbone significantly improved immunoreactivity in the synovium compared to Channa striatus extract in monosodium iodoacetate (MIA)-induced knee osteoarthritis in rat. Journal of Medicinal Plants Research, 5(9), 1701–1710.
Ali, S. S., Ahsan, H., Zia, M. K., Siddiqui, T., & Khan, F. H. (2020). Understanding oxidants and antioxidants: Classical team with new players. Journal of Food Biochemistry, 44(3), 1–13.
Arulselvan, P., Fard, M. T., Tan, W. S., Gothai, S., Fakurazi, S., Norhaizan, M. E., & Kumar, S. S. (2016). Role of Antioxidants and Natural Products in Inflammation. Oxidative Medicine and Cellular Longevity, 2016.
Ashraf, S. M., Sebastian, J., & Rathinasamy, K. (2019). Zerumbone, a cyclic sesquiterpene, exerts antimitotic activity in HeLa cells through tubulin binding and exhibits synergistic activity with vinblastine and paclitaxel. Cell Proliferation, 52(2).
Aziz, R. S., Siddiqua, A., Shahzad, M., Shabbir, A., & Naseem, N. (2019). Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels. Biomedicine and Pharmacotherapy, 110(November 2018), 554–560.
Behl, P., Edwards, J. D., Kiss, A., Lanctot, K. L., Streiner, D. L., Black, S. E., & Stuss, D. T. (2014). Treatment effects in multiple cognitive domains in Alzheimer’s disease: a two-year cohort study. Alzheimer’s Research & Therapy, 6(4), 48.
Behl, T., Kumar, K., Brisc, C., Rus, M., Nistor-Cseppento, D. C., Bustea, C., Aron, R. A. C., Pantis, C., Zengin, G., Sehgal, A., Kaur, R., Kumar, A., Arora, S., Setia, D., Chandel, D., & Bungau, S. (2021). Exploring the multifocal role of phytochemicals as immunomodulators. Biomedicine and Pharmacotherapy, 133(November 2020), 110959.
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014). Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews, 94(2), 329–354.
Bilitewski, U. (2008). Determination of immunomodulatory effects : focus on functional analysis of phagocytes as representatives of the innate immune system. Anal Bioanal Chem, 1545–1554.
Chen, B.-Y., Lin, D. P.-C., Su, K.-C., Chen, Y.-L., Wu, C.-Y., Teng, M.-C., Tsai, Y.-T., Sun, C.-Y., Wang, S.-R., & Chang, H.-H. (2011). Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse. Molecular Vision, 17, 723. /pmc/articles/PMC3060159/
Chia, J. S. M., Izham, N. A. M., Farouk, A. A. O., Sulaiman, M. R., Mustafa, S., Hutchinson, M. R., & Perimal, E. K. (2020). Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models. In Frontiers in Pharmacology (Vol. 11).
Chia, J. S. M., Omar Farouk, A. A., Mohamad, A. S., Sulaiman, M. R., & Perimal, E. K. (2016). Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors. Biomedicine and Pharmacotherapy, 83, 1303–1310.
Chien, T.-Y., Huang, S. K.-H., Lee, C.-J., Tsai, P.-W., & Wang, C.-C. (2016). Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis. International Journal of Molecular Sciences, 17(2), 249.
Dai, C., Xiao, X., Li, D., Tun, S., Wang, Y., Velkov, T., & Tang, S. (2018). Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis. Cell Death and Disease, 9(12).
Deorukhkar, A., Ahuja, N., Mercado, A.-L., Diagaradjane, P., Raju, U., Patel, N., Mohindra, P., Diep, N., Guha, S., & Krishnan, S. (2015). Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Medicine, 4(2), 278.
Dev, S. (1960). Studies in sesquiterpenes—XVI : Zerumbone, a monocyclic sesquiterpene ketone. Tetrahedron, 8(3–4), 171–180.
Dev, S., Anderson, J. E., Cormier, V., Damodaran, N. P., & Roberts, J. D. (2002). Nuclear magnetic resonance spectroscopy. The conformational mobility of humulene and zerumbone. Journal of the American Chemical Society, 90(5), 1246–1248.
Duronio, R. J., & Xiong, Y. (2013). Signaling Pathways that Control Cell Proliferation. Cold Spring Harb Perspect Biol.
Eid, E. E. M., Alanazi, A. S., Koosha, S., Alrasheedy, A. A., Azam, F., Taban, I. M., Khalilullah, H., Al-Qubaisi, M. S., & Alshawsh, M. A. (2019). Zerumbone Induces Apoptosis in Breast Cancer Cells by Targeting αvβ3 Integrin upon Co-Administration with TP5-iRGD Peptide. Molecules, 24(14).
Esquivel-Chirino, C., Esquivel-Soto, J., Morales-Gonzales, J. A., Sanches, D. M., Ventura-Gallegos, J. L., Hernandes-Mora, L. E., & Zentella-Dehesa, A. (2016). Inflammatory Environmental, Oxidative Stress in Tumoral Progression. Intech, i(tourism), 13.
García-Sánchez, A., Miranda-Díaz, A. G., & Cardona-Muñoz, E. G. (2020). The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- And Antioxidant Properties in Chronic Diseases. Oxidative Medicine and Cellular Longevity, 2020.
Girisa, S., Shabnam, B., Monisha, J., Fan, L., Halim, C. E., Arfuso, F., Ahn, K. S., Sethi, G., & Kunnumakkara, A. B. (2019). molecules Potential of Zerumbone as an Anti-Cancer Agent.
Gopalsamy, B., Chia, J. S. M., Farouk, A. A. O., Sulaiman, M. R., & Perimal, E. K. (2020). Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain. Molecules, 25(17), 3880.
Gopalsamy, B., Farouk, A. A. O., Mohamad, T. A. S. T., Sulaiman, M. R., & Perimal, E. K. (2017). Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain. Journal of Pain Research, 10, 2605.
Hamid, A., Lee, L. S., Karim, S. R., & Jufri, N. F. (2018). Hepatoprotective Effects of Zerumbone against Paracetamol-Induced Acute Hepatotoxicity in Rats. Malays J Med Sci.
He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017). Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species. Cellular Physiology and Biochemistry, 44(2), 532–553.
Hemn, H. O., Noordin, M. M., Rahman, H. S., Hazilawati, H., Zuki, A., & Chartrand, M. S. (2015). Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits. Drug Design, Development and Therapy, 9, 4173.
Heneka, M. T., Carson, M. J., Khoury, J. El, Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., … Kummer, M. P. (2015). Neuroinflammation in Alzheimer’s Disease. The Lancet. Neurology, 14(4), 388.
Hensley, K. (2010). Neuroinflammation in Alzheimer’s disease: Mechanisms, pathologic consequences, and potential for therapeutic manipulation. Journal of Alzheimer’s Disease, 21(1), 1–14.
Hinson, J. A., Roberts, D. W., & James, L. P. (2010). Mechanisms of Acetaminophen-Induced Liver Necrosis. Handbook of Experimental Pharmacology, 196(196), 369.
Ho, Y. C., Lee, S. S., Yang, M. L., Huang-Liu, R., Lee, C. Y., Li, Y. C., & Kuan, Y. H. (2017). Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFκB pathway. Chemico-Biological Interactions, 271, 9–14.
Hseu, Y. C., Huang, Y. C., Korivi, M., Wu, J. J., Way, T. Der, Ou, T. T., Chiu, L. W., Lee, C. C., Lin, M. L., & Yang, H. L. (2015). Zerumbone attenuates TGF-β1-mediated epithelial–mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells. Journal of Functional Foods, 18, 58–72.
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C. B., & Rahu, N. (2016). Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxidative Medicine and Cellular Longevity, 2016.
Hwang, J., Youn, K., Ji, Y., Lee, S., Lim, G., Lee, J., Ho, C.-T., Leem, S.-H., & Jun, M. (2020). Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients, 12(5).
Hwang, S., Jo, M., Hong, J. E., Park, C. O., Lee, C. G., Yun, M., & Rhee, K.-J. (2019). Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ. International Journal of Molecular Sciences, 20(18).
Ilari, S., Giancotti, L. A., Lauro, F., Dagostino, C., Gliozzi, M., Malafoglia, V., Sansone, L., Palma, E., Tafani, M., Russo, M. A., Tomino, C., Fini, M., Salvemini, D., Mollace, V., & Muscoli, C. (2020). Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control. Pharmacological Research, 157(May).
Ilari, S., Giancotti, L. A., Lauro, F., Gliozzi, M., Malafoglia, V., Palma, E., Tafani, M., Russo, M. A., Tomino, C., Fini, M., Salvemini, D., Mollace, V., & Muscoli, C. (2020). Natural antioxidant control of neuropathic pain— exploring the role of mitochondrial sirt3 pathway. Antioxidants, 9(11), 1–19.
Jaeschke, H., & Bajt, M. L. (2006). Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicological Sciences, 89(1), 31–41.
Jafariana, S., Ling, K.-H., Hassan, Z., Perimal-Lewis, L., Sulaiman, M. R., & Perimala, E. K. (2019). Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats. Alzheimer’s & Dementia (New York, N. Y.), 5, 637–643.
Jalili-Nik, M., Sadeghi, M. M., Mohtashami, E., Mollazadeh, H., Afshari, A. R., & Sahebkar, A. (2020). Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation. Oxidative Medicine and Cellular Longevity, 2020.
Jantan, I., Haque, M. A., Ilangkovan, M., & Arshad, L. (2019). Zerumbone from Zingiber zerumbet inhibits innate and adaptive immune responses in Balb/C mice. International Immunopharmacology, 73, 552–559.
Jeon, M., Han, J., Nam, S. J., Lee, J. E., & Kim, S. (2016). Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone. Chemico-Biological Interactions, 258, 126–133.
Jiang, D., Rasul, A., Batool, R., Sarfraz, I., Hussain, G., Mateen Tahir, M., Qin, T., Selamoglu, Z., Ali, M., Li, J., & Li, X. (2019). Potential Anticancer Properties and Mechanisms of Action of Formononetin. BioMed Research International, 2019.
Jorvig, J. E., & Chakraborty, A. (2015). Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity. Anti-Cancer Drugs, 26(2), 160–166.
Kabeer, F. A., Rajalekshmi, D. S., Nair, M. S., & Prathapan, R. (2017). Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells. Integrative Medicine Research, 6(2), 190.
Kalantari, K., Moniri, M., Moghaddam, A. B., Rahim, R. A., Ariff, A. Bin, Izadiyan, Z., & Mohamad, R. (2017). A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extraction from Ginger Rhizomes. Molecules 2017, Vol. 22, Page 1645, 22(10), 1645.
Kim, S., Lee, J., Jeon, M., Lee, J. E., & Nam, S. J. (2016). Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-β1 signaling pathway. Oncotarget, 7(2), 1544.
Klein, W. L., Stine, W. B., & Teplow, D. B. (2004). Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease. Neurobiology of Aging, 25(5), 569–580.
Leung, W. S., Yang, M. L., Lee, S. S., Kuo, C. W., Ho, Y. C., Huang-Liu, R., Lin, H. W., & Kuan, Y. H. (2017). Protective effect of zerumbone reduces lipopolysaccharide-induced acute lung injury via antioxidative enzymes and Nrf2/HO-1 pathway. International Immunopharmacology, 46, 194–200.
Li, Lei, Wu, X.-H., Zhao, X.-J., Xu, L., Pan, C.-L., & Zhang, Z.-Y. (2020). Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling. Journal of Neuroinflammation, 17(1).
Li, Liqing, Kong, L., & Song, H. (2017). The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms. Experimental and Therapeutic Medicine, 14(3), 2505–2510.
Lingappan, K. (2017). NF-κB in Oxidative Stress. Curr Opin Toxicol., 7, 81–86.
Liu, W. Y., Tzeng, T. F., & Liu, I. M. (2016). Zerumbone, a bioactive sesquiterpene, ameliorates diabetes-induced retinal microvascular damage through inhibition of phospho-p38 mitogen-activated protein kinase and nuclear factor-κB pathways. Molecules, 21(12).
Long, J. M., & Holtzman, D. M. (2019). Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell, 179(2), 312.
Lv, T., Zhang, W., & Han, X. (2018). Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway. Oncology Letters, 15(5), 7603.
Ma, S., Lei, Y., Zhang, L., & Wang, J. (2018). Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels. Oncology Letters, 16(4), 4379.
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014). Reactive Oxygen Species in Inflammation and Tissue Injury. Antioxidants & Redox Signaling, 20(7), 1126.
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, 2017.
Rahman, H. S., Rasedee, A., How, C. W., Zeenathul, N. A., Chartrand, M. S., Yeap, S. K., Abdul, A. B., Tan, S. W., Othman, H. H., Ajdari, Z., Namvar, F., Arulselvan, P., Fakurazi, S., Mehrbod, P., Daneshvar, N., & Begum, H. (2015). Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model. International Journal of Nanomedicine, 10, 1649.
Rahman, H. S., Rasedee, A., Yeap, S. K., Othman, H. H., Chartrand, M. S., Namvar, F., Abdul, A. B., & How, C. W. (2014). Biomedical properties of a natural dietary plant metabolite, Zerumbone, in cancer therapy and chemoprevention trials. BioMed Research International, 2014.
Reid, G. A., Chilukuri, N., & Darvesh, S. (2013). Butyrylcholinesterase and the cholinergic system. Neuroscience, 234, 53–68.
Reyes-Gordillo, K., Shah, R., & Muriel, P. (2017). Oxidative Stress and Inflammation in Hepatic Diseases: Current and Future Therapy. Oxidative Medicine and Cellular Longevity, 2017(ii).
Safakhah, H. A., Kor, N. M., Bazargani, A., Bandegi, A. R., Pourbadie, H. G., Khoshkholgh-Sima, B., & Ghanbari, A. (2017). Forced exercise attenuates neuropathic pain in chronic constriction injury of male rat: An investigation of oxidative stress and inflammation. Journal of Pain Research, 10, 1457–1466.
Salehi, B., Ata, A., Kumar, N. V. A., Sharopov, F., Ramírez-Alarcón, K., Ruiz-Ortega, A., Ayatollahi, S. A., Fokou, P. V. T., Kobarfard, F., Zakaria, Z. A., Iriti, M., Taheri, Y., Martorell, M., Sureda, A., Setzer, W. N., Durazzo, A., Lucarini, M., Santini, A., Capasso, R., … Sharifi-Rad, J. (2019). Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules, 9(10).
Samad, N. A., Abdul, A. B., Rahman, H. S., Rasedee, A., Ibrahim, T. A. T., & Keon, Y. S. (2017). Zerumbone Suppresses Angiogenesis in HepG2 Cells through Inhibition of Matrix Metalloproteinase-9, Vascular Endothelial Growth Factor, and Vascular Endothelial Growth Factor Receptor Expressions. Pharmacognosy Magazine, 13 (Suppl(62), 179–188.
Sehrawat, A., Arlotti, J. A., Murakami, A., & Singh, S. V. (2012). Zerumbone causes Bax and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast Cancer Research and Treatment, 136(2), 429.
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011). Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 1(1).
Shamoto, T., Matsuo, Y., Shibata, T., Tsuboi, K., Nagasaki, T., Takahashi, H., Funahashi, H., Okada, Y., & Takeyama, H. (2014). Zerumbone inhibits angiogenesis by blocking NF-κB activity in pancreatic cancer. Pancreas, 43(3), 396–404.
Shams, S. G. E., & Eissa, R. G. (2022). Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-κB pathways. Heliyon, 8(10), e11159.
Shoaib, M., Shah, I., Ali, N., Adhikari, A., Tahir, M. N., Shah, S. W. A., Ishtiaq, S., Khan, J., Khan, S., & Umer, M. N. (2017). Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem. BMC Complementary and Alternative Medicine, 17(1), 1–11.
Shyanti, R. K., Sehrawat, A., Singh, S. V., Mishra, J. P. N., & Singh, R. P. (2017). Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells. Toxicology in Vitro, 44, 74–84.
Sidahmed, H. M. A., Hashim, N. M., Abdulla, M. A., Ali, H. M., Mohan, S., Abdelwahab, S. I., Taha, M. M. E., Fai, L. M., & Vadivelu, J. (2015). Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith. PLoS ONE, 10(3).
Su, C. C., Wang, S. C., Chen, I. C., Chiu, F. Y., Liu, P. L., Huang, C. H., Huang, K. H., Fang, S. H., Cheng, W. C., Huang, S. P., Yeh, H. C., Liu, C. C., Lee, P. Y., Huang, M. Y., & Li, C. Y. (2021). Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages. Frontiers in Pharmacology, 12(May), 1–12.
Sulaiman, M. R., Perimal, E. K., Akhtar, M. N., Mohamad, A. S., Khalid, M. H., Tasrip, N. A., Mokhtar, F., Zakaria, Z. A., Lajis, N. H., & Israf, D. A. (2010). Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81(7), 855–858.
Suzuki, H., Nishizawa, T., Tsugawa, H., Mogami, S., & Hibi, T. (2012). Oxidative Stress in Stomach Disorders. J. Clin. Biochem. Nutr., 50(1), 35–39.
Truong, V. Van, Duy, T., Ngoc, T., Thi, N., & Minh, P. (2015). Synthesis and Anti-proliferative Activity of Novel Azazerumbone Conjugates with Chalcones Bioorganic & Medicinal Chemistry Letters Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalcones. Bioorganic & Medicinal Chemistry Letters, 25(22), 5182–5185.
Truong, V. Van, Nam, T. D., Hung, T. N., Nga, N. T., Quan, P. M., Chinh, L. Van, & Jung, S. H. (2015). Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalcones. Bioorganic and Medicinal Chemistry Letters, 25(22), 5182–5185.
Tsuboi, K., Matsuo, Y., Shamoto, T., Shibata, T., Koide, S., Morimoto, M., Guha, S., Sung, B., Aggarwal, B. B., Takahashi, H., & Takeyama, H. (2014). Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncology Reports, 31(1), 57–64.
Tzeng, T.-F., Liou, S.-S., Chang, C. J., & Liu, I.-M. (2013a). Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Evidence-Based Complementary and Alternative Medicine : ECAM, 2013.
Tzeng, T.-F., Liou, S.-S., Chang, C. J., & Liu, I.-M. (2013b). Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response. Nutrition & Metabolism, 10(1), 64.
Tzeng, T.-F., Liou, S.-S., Tzeng, Y.-C., & Liu, I.-M. (2016). Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats. Nutrients, 8(8).
Vigneron, A., & Vousden, K. H. (2010). p53, ROS and senescence in the control of aging. Aging (Albany NY), 2(8), 471.
Wang, C., Zou, S., Cui, Z., Guo, P., Meng, Q., Shi, X., Gao, Y., Yang, G., & Han, Z. (2015). Zerumbone protects INS-1 rat pancreatic beta cells from high glucose-induced apoptosis through generation of reactive oxygen species. Biochemical and Biophysical Research Communications, 460(2), 205–209.
Wang, D., Li, Y., Cui, P., Zhao, Q., Tan, B. bo, Zhang, Z. dong, Liu, Y., & Jia, N. (2016). Zerumbone induces gastric cancer cells apoptosis: Involving cyclophilin A. Biomedicine & Pharmacotherapy, 83, 740–745.
Wang, M., Niu, J., Gao, L., Gao, Y., & Gao, S. (2019). Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination. Biomedicine & Pharmacotherapy, 109, 2447–2455.
Wang, M., Niu, J., Ou, L., Deng, B., Wang, Y., & Li, S. (2019). Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway. Molecules, 24(10).
Weng, H. Y., Hsu, M. J., Wang, C. C., Chen, B. C., Hong, C. Y., Chen, M. C., Chiu, W. T., & Lin, C. H. (2012). Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. Journal of Biomedical Science, 19(1), 1–11.
Wenhong, D., Jia, Y., Weixing, W., Xiaoyan, C., Chen, C., Sheng, X., & Hao, J. (2012). Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury. Mediators of Inflammation, 2012, 12.
Xu, D.-P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J. J., & Li, H. Bin. (2017). Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. International Journal of Molecular Sciences, 18(1), 20–31.
Xu, M., Rui, D., Yan, Y., Xu, S., Niu, Q., Feng, G., Wang, Y., Li, S., & Jing, M. (2017). Oxidative Damage Induced by Arsenic in Mice or Rats: A Systematic Review and Meta-Analysis. Biological Trace Element Research, 176(1), 154–175.
Yan, H., Ren, M. Y., Wang, Z. X., Feng, S. J., Li, S. I., Cheng, Y. I., Hu, C. X., Gao, S. Q., & Zhang, G. Q. (2017). Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions. Oncology Letters, 13(4), 2397–2402.
Zainal, N. S., Gan, C. P., Lau, B. F., Yee, P. S., Tiong, K. H., Abdul Rahman, Z. A., Patel, V., & Cheong, S. C. (2018). Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells. Phytomedicine, 39, 33–41.
Zhang, S., Liu, Q., Liu, Y., Qiao, H., & Liu, Y. (2012a). Zerumbone, a Southeast Asian ginger sesquiterpene, induced apoptosis of pancreatic carcinoma cells through p53 signaling pathway. Evidence-Based Complementary and Alternative Medicine, 2012, 12–15.
Zhang, S., Liu, Q., Liu, Y., Qiao, H., & Liu, Y. (2012b). Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine : ECAM, 2012.
How to Cite
Doloking, H., Lallo, S., Manggau, M. A., & Rifai, Y. (2023). Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review. Ad-Dawaa’ Journal of Pharmaceutical Sciences, 6(2), 1-23.
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