Potential of Thibbun Nabawi Habbatusauda (Nigella sativa); Review of the Active Pharmacological Timoquinone
Keywords:
Habbatusauda, Nigella sativa, Thibbun Nabawi
Abstract
Habbatusauda or Black Seed or Black Cumin (Nigella sativa) has been widely mentioned in various Islamic studies, including its potential as a "cure for all diseases except death. The hadith can be interpreted as improving immunity and enhancing memory (physical and cognitive aspects). Scientifically, the high content of thymoquinone and DHA in Black Seed plays a major role as an immunomodulator and brain nutrition. Black Seed contains both hydrophilic and lipophilic compounds. Amino acids, proteins, carbohydrates, essential oils, fixed oils, sterols, alkaloids, saponins and crude fiber, and minerals, thymoquinone, p-cymene, longifoline thujene, carvacrol, cubebene, pinene, limonene, pinene, sabinene are the ingredients. Timoquinone is present at a concentration of 3.5-8.7 mg/g in oil. Black Seed Oil is also high in DHA (3%). The content of the active compound Timoquinone is most responsible for its wide range of effects.
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References
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A. Badar, H. K. (2017). “Efect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: Nonrandomized clinical trial. Annals of Saudi Medicine, 37(1), 56–63.
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A. F. Bafgh, A. R. (2011). The in vivo antileishmanial activity of alcoholic extract from Nigella sativa seeds. African Journal of Microbiology Research, 5(12), 1504–1510.
A. Onifade, A. J. (2013). Nigella Sativa Concoction induced sustained seroreversion in HIV patient. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 332–335.
A. Piras, A. R. (2013). Chemical composition and in vitro bioactivity of the volatile and fxed oils of Nigella sativa L. extracted by supercritical carbon dioxide. Industrial Crops and Products, 46, 317–323.
A. Rizka, S. S. (2017). “Efect of Nigella sativa seed extract for hypertension in elderly: a double-blind randomized controlled trial. Acta Medica Indonesiana, 49(4), 307–313.
A. Zakaria, M. R. (2018). Analgesic properties antipyretic activity of Nigella sativa and Eucheuma Cottonii extracts. Journal of Natural Science, Biology and Medicine, 9(1), 23–26.
Abdelrazek, H. M. (2018). Black seed and thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats. Oxidative Medicine and Cellular Longevity, 2018.
Adam, G. O. (2016). Hepatoprotective effects ofNigella sativaseed extract against acetaminophen-induced oxidativestress. Asian Pacific Journal of Tropical Medicine, 9(3), 221-227.
Akrom. (2019). Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene. Indonesian Journal of Cancer Chemoprevention, 10(3), 140-148.
Al-Ghamdi, M. S. (2001). The anti-infammatory, analgesic and antipyretic activity of Nigella sativa. Journal of Ethnopharmacology, 76(1), 45-48.
Arici, M. (2005). Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites, 56(4), 259-262.
Aslam, H. (2018). Immunomodulatory effect of thymoquinone on atopic dermatitis. Molecular Immunology, 101, 276-283.
B. K. Das, U. K. (2014). Analgesic and anti-infammatory activities of the fruit extract of Ampelocissus latifolia(Roxb) on laboratory animals. British Journal of Pharmaceutical Research, 4(12), 1477–1485.
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F. Shahid, Z. F. (2018). Oral Nigella sativa oil and thymoquinone administration ameliorates the efect of long-term cisplatin treatment on the enzymes of carbohydrate metabolism, brush border membrane, and antioxidant defense in rat intestine. Naunyn-Schmiedeberg’s Archives of Pharmacology, 391(2), 145–157.
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H. Kaatabi, A. O. (2012). Favorable impact of Nigella sativa seeds on lipid profle in type 2 diabetic patients. Journal of Family and Community Medicine, 19(3), 155–160.
H. Kaatabi, A. O. (2015). Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS ONE, 10(2).
H. Omidi, S. K. (2017). Efects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes. Biomedicine & Pharmacotherapy, 96, 1335–1340.
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Hajiri, A. Z., Abdillah, D. S., & Zulfikar, M. Q. (2020). A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativafor Osteoarthritis. International Islamic Medical Journal, 68-73.
Isaev, N. K. (2020). Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Biochemistry (Moscow), 85(2), 167176.
K. Jaarin, W. D. (2015). Mechanisms of the antihypertensive efects of Nigella sativa oil in L-NAME induced hypertensive rats. Clinics, 70(11), 751–757.
Keshavarzi, Z. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. Biofactors, 45(4), 517-535.
KhanAR, K. K. (2016). Wide spectrum antibacterial activity of Nigella sativa L seeds. IOSR Journal of Pharmacy, 6(7), 12-16.
Kooti, W. (2016). Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chinese Journal of Natural Medicines, 14(10), 0732-0745.
Kuldeep, S. R. (2011). Pharmacognosy and pharmacology of Nigella sativa. International Research Journal of Pharmacy, 2(11), 36-39.
Kulyar, M. F.-e.-A. (2020). Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic . Phytomedicine.
Lupoli, F. (2018). The role of oxidative stress in Friedreich’s ataxia. FEBS Letters, 592(5), 718–727.
M. A. Assi, M. H. (2016). The various efects of Nigella sativa on multiple body systems in human and animals. Pertanika Journal of Scholarly Research Reviews, 2(3), 1-19.
M. A. Wilson, C. A. (2015). Stress as a one-armed bandit: Diferential efects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala. Neurobiology of Stress, 1, 195–208.
M. E. Abd El-Hack, M. A. (2016). Nutritional, healthical and therapeutic efcacy of black cumin (Nigella sativa) in animals, poultry and humans. International Journal of Pharmacology, 12(3), 232–248.
M. Hosseini, T. M. (2015). Efects of the hydroalcoholic extract of Nigella Sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese Journal of Integrative Medicine, 21(6), 438–444.
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Mahmoudvand, H. (2014). Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains. Journal of Medical Mycology, 24(4), e155-e161.
Mostafa. (2015). Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species. Pathophysiologi, 22(1), 49-55.
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Park, H. M. (2012). Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. Journal of ethnopharmacology, 141(3), 1071-1076.
Qureshi, M. U. (2010). Analgesic efect of Nigella sativa seeds extract on experimentally induced pain in albino mice. Journal of the College of Physicians and Surgeons Pakistan, 20(7), 464–467.
R. Daryabeygi-Khotbehsara, M. G. (2017). Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta analysis. Complementary Terapies in Medicine, 35, 6-13.
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R. M. Mostafa, Y. M. (2013). Antioxidant efect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women. SAGE Open Medicine.
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Samarghandian, S. (2018). A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases. CNS & Neurological Disorders - Drug Targets, 17, 412-420.
Shaterzadeh-Yazdi, H. (2018). Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovascular & Haematological Disorders-Drug Targets, 18, 52-60.
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Sontakke. (2002). A duality in the roles of. Clinica Chimica Acta, 318(1-2), 145–148.
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A. Bamosa, H. K. (2015). Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus. Journal of Family and Community Medicine (JFCM), 22(2), 88–95.
A. F. Bafgh, A. R. (2011). The in vivo antileishmanial activity of alcoholic extract from Nigella sativa seeds. African Journal of Microbiology Research, 5(12), 1504–1510.
A. Onifade, A. J. (2013). Nigella Sativa Concoction induced sustained seroreversion in HIV patient. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 332–335.
A. Piras, A. R. (2013). Chemical composition and in vitro bioactivity of the volatile and fxed oils of Nigella sativa L. extracted by supercritical carbon dioxide. Industrial Crops and Products, 46, 317–323.
A. Rizka, S. S. (2017). “Efect of Nigella sativa seed extract for hypertension in elderly: a double-blind randomized controlled trial. Acta Medica Indonesiana, 49(4), 307–313.
A. Zakaria, M. R. (2018). Analgesic properties antipyretic activity of Nigella sativa and Eucheuma Cottonii extracts. Journal of Natural Science, Biology and Medicine, 9(1), 23–26.
Abdelrazek, H. M. (2018). Black seed and thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats. Oxidative Medicine and Cellular Longevity, 2018.
Adam, G. O. (2016). Hepatoprotective effects ofNigella sativaseed extract against acetaminophen-induced oxidativestress. Asian Pacific Journal of Tropical Medicine, 9(3), 221-227.
Akrom. (2019). Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene. Indonesian Journal of Cancer Chemoprevention, 10(3), 140-148.
Al-Ghamdi, M. S. (2001). The anti-infammatory, analgesic and antipyretic activity of Nigella sativa. Journal of Ethnopharmacology, 76(1), 45-48.
Arici, M. (2005). Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas y Aceites, 56(4), 259-262.
Aslam, H. (2018). Immunomodulatory effect of thymoquinone on atopic dermatitis. Molecular Immunology, 101, 276-283.
B. K. Das, U. K. (2014). Analgesic and anti-infammatory activities of the fruit extract of Ampelocissus latifolia(Roxb) on laboratory animals. British Journal of Pharmaceutical Research, 4(12), 1477–1485.
Beg, ]. S. (2016). “Evaluation of therapeutic efect of omega-6 linoleic acid and thymoquinone enriched extracts from Nigella sativa oil in the mitigation of lipidemic oxidative stress in rats. Nutrition Journal, 32(6), p. 649–655.
C. Wright, S. M. (2014). Sperm DNA damage caused by oxidative stress: modifable clinical, lifestyle and nutritional factors in male infertility. Reproductive BioMedicine Online, 28(6), 684–703.
Cappuccio. (1999). High blood pressure and bone-mineral loss in elderly white. The lancet, 354(9183), 971–975.
Cascella, M. (2018). Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease. Front Aging Neurosci.
Catanzaro, M. (2018). Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea. Molecules, 23(2778), 1-17.
Christensen. (1999). Bone mineral in pre- and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus. Osteoporosis International, 10(4), 307–311.
E. M. F. Barakat, L. M. (2013). Efects of Nigella sativa on outcome of hepatitis C in Egypt. World Journal of Gastroenterology, 10(5), 2529–2536.
Emeka, L. B. (2015). Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds. Pak J Pharm Sci.
Erisgin, Z. (2019). Protective effects of Nigella sativa oil against carboplatin-induced liverdamage in rats. Biomedicine & Pharmacotherapy, 110(2019), 742-747.
F. Forouzanfar, B. S. (2014). Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial efects. Iranian Journal of Basic Medical Sciences, 17(12), 929–938.
F. M. Awah, P. N. (2012). Free radical scavenging activity, phenolic contents and cytotoxicity of selected Nigerian medicinal plants. Food Chemistry, 131(4), 1279–1286.
F. Shahid, Z. F. (2018). Oral Nigella sativa oil and thymoquinone administration ameliorates the efect of long-term cisplatin treatment on the enzymes of carbohydrate metabolism, brush border membrane, and antioxidant defense in rat intestine. Naunyn-Schmiedeberg’s Archives of Pharmacology, 391(2), 145–157.
G. Kaur, M. I. (2018). A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus. Journal of Ayurveda and Integrative Medicine, 9(1), 27–37.
H. A. El Rabey, M. N.-S. (2017). Te antidiabetic activity of Nigella sativa and propolis on streptozotocin-induced diabetes and diabetic nephropathy in male rats. Evidence-Based Complementary and Alternative Medicine, 2017.
H. Kaatabi, A. O. (2012). Favorable impact of Nigella sativa seeds on lipid profle in type 2 diabetic patients. Journal of Family and Community Medicine, 19(3), 155–160.
H. Kaatabi, A. O. (2015). Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS ONE, 10(2).
H. Omidi, S. K. (2017). Efects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes. Biomedicine & Pharmacotherapy, 96, 1335–1340.
Hackshaw, M. R. (1997). A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. British Medical Journal, 315(7112), 841–846.
Hajiri, A. Z., Abdillah, D. S., & Zulfikar, M. Q. (2020). A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativafor Osteoarthritis. International Islamic Medical Journal, 68-73.
Isaev, N. K. (2020). Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Biochemistry (Moscow), 85(2), 167176.
K. Jaarin, W. D. (2015). Mechanisms of the antihypertensive efects of Nigella sativa oil in L-NAME induced hypertensive rats. Clinics, 70(11), 751–757.
Keshavarzi, Z. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. Biofactors, 45(4), 517-535.
KhanAR, K. K. (2016). Wide spectrum antibacterial activity of Nigella sativa L seeds. IOSR Journal of Pharmacy, 6(7), 12-16.
Kooti, W. (2016). Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chinese Journal of Natural Medicines, 14(10), 0732-0745.
Kuldeep, S. R. (2011). Pharmacognosy and pharmacology of Nigella sativa. International Research Journal of Pharmacy, 2(11), 36-39.
Kulyar, M. F.-e.-A. (2020). Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic . Phytomedicine.
Lupoli, F. (2018). The role of oxidative stress in Friedreich’s ataxia. FEBS Letters, 592(5), 718–727.
M. A. Assi, M. H. (2016). The various efects of Nigella sativa on multiple body systems in human and animals. Pertanika Journal of Scholarly Research Reviews, 2(3), 1-19.
M. A. Wilson, C. A. (2015). Stress as a one-armed bandit: Diferential efects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala. Neurobiology of Stress, 1, 195–208.
M. E. Abd El-Hack, M. A. (2016). Nutritional, healthical and therapeutic efcacy of black cumin (Nigella sativa) in animals, poultry and humans. International Journal of Pharmacology, 12(3), 232–248.
M. Hosseini, T. M. (2015). Efects of the hydroalcoholic extract of Nigella Sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese Journal of Integrative Medicine, 21(6), 438–444.
M. K. A. Sahak, N. K. (2016). Te Role of Nigella sativa and its active constituents in learning and memory. Evidence-Based Complementary and Alternative Medicine, 2016.
M. Kolahdooz, S. N. (2014). Efects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo controlled clinical trial. Phytomedicine, 21(6), 901–905.
Mahmoudvand, H. (2014). Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains. Journal of Medical Mycology, 24(4), e155-e161.
Mostafa. (2015). Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species. Pathophysiologi, 22(1), 49-55.
N. Namazi, R. M. (2015). “Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind. Phytotherapy Research, 29(11), 1722–1728.
N. Ozdemir, M. N.-E. (2018). Efect of black cumin oil on the oxidative stability and sensory characteristics of mayonnaise. Journal of Food Science and Technolog, 55(4), 1562–1568.
O. K. Vasant, B. G. (2012). Antihypertensive and diuretic efects of the aqueous extract of Colocasia esculenta Linn. leaves in experimental paradigms. Iranian Journal of Pharmaceutical Research, 11(2), 621–634.
P. N. R. Rachman, A. a. (2017). The efcacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk. Proceedings of the International Pharmacy Conference, 259. Indonesia.
Padwa, H. P. (2017). Evaluation of anti-infammatory activity of Nigella sativa: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology, 7(7), 707-711.
Park, H. M. (2012). Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. Journal of ethnopharmacology, 141(3), 1071-1076.
Qureshi, M. U. (2010). Analgesic efect of Nigella sativa seeds extract on experimentally induced pain in albino mice. Journal of the College of Physicians and Surgeons Pakistan, 20(7), 464–467.
R. Daryabeygi-Khotbehsara, M. G. (2017). Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta analysis. Complementary Terapies in Medicine, 35, 6-13.
R. J. Aitken, T. B. (2014). Oxidative stress and male reproductive health. Asian Journal of Andrology, 16(1), 31–38.
R. M. Mostafa, Y. M. (2013). Antioxidant efect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women. SAGE Open Medicine.
R. Parandin, N. Y. (2012). The enhancing efects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats. Iranian Journal of Reproductive Medicine, 10(4), 355-362.
Rizky, D. M., Firmansyah, E., & Darmalaksana, W. (2021). Takhrij and Syarah Hadith of Agrotechnology Study of Black Cumin Plants as Medicine. Conference on Islamic and Socio-Cultural Studies (CISS) .
S. H. Aljabre, O. M. (2015). Dermatological efects of Nigella sativa. Journal of Dermatology & Dermatologic Surgery, 19(2), 92–96.
S. S. Ashraf, M. V. (2011). Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress. Journal of Chromatographic Science (JCS), 49(4), 321–326.
Samarghandian, S. (2018). A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases. CNS & Neurological Disorders - Drug Targets, 17, 412-420.
Shaterzadeh-Yazdi, H. (2018). Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovascular & Haematological Disorders-Drug Targets, 18, 52-60.
Shokri, H. (2016). A review on the inhibitory potential of Nigella sativa against pathogenic and toxigenic fungi. Avicenna Journal of Phytomedicine, 6(1), 21–33.
Shuid, A. N. (2012). Nigella sativa: A Potential Antiosteoporotic Agent. Evidence-Based Complementary and Alternative Medicine.
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Published
2021-12-01
How to Cite
Mardan, M., Ismail, I., & Rauf, A. (2021). Potential of Thibbun Nabawi Habbatusauda (Nigella sativa); Review of the Active Pharmacological Timoquinone. Ad-Dawaa’ Journal of Pharmaceutical Sciences, 4(2), 108-125. Retrieved from https://journal3.uin-alauddin.ac.id/index.php/addawaa/article/view/53474
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