Development of Novel Alumina by Solid-State Reaction for 99Mo/99mTc Adsorbent Material
Abstract
Technetium-99m (99mTc), a daughter radionuclide of molybdenum-99 (99Mo), is the most widely used radiodiagnostic agent due to its ideal characteristics. The separation of this radionuclide from 99Mo is commonly performed using alumina. However, a new production method of this radionuclide, which employs a low specific activity 99Mo, makes alumina no longer suitable as separation material. This study aims to develop novel alumina using a facile solid-state reaction for 99Mo/99mTc generator system. The SS-alumina was synthesized from aluminium nitrate nonahydrate and ammonium bicarbonate without solvent. The resulted SS-alumina was then analyzed by FTIR and BET method. 99Mo adsorption and 99mTc releasing study on a series of pH were also performed. FTIR study revealed that the resulting material was Al2O3 with a surface area of 237.65 m2/g. The adsorption capacity, 99mTc yield, 99Mo breakthrough, and alumina breakthrough were 76.06 mg Mo/g alumina, 80.31%, 56.5 µCi/mCi 99mTc, and less than 5 mg/mL, respectively. The elution profile shows a high activity of 99mTc in 2nd and 3rd fraction. It is concluded that the SS-alumina shows good performance as adsorbent material for separation of a 99Mo/99mTc and further work is now underway.
Downloads
References
Blaauw, M., Ridikas, D., Baytelesov, S., Salas, P. S. B., Chakrova, Y., Eun-Ha, C., … Van Dong Duong. (2017). Estimation of 99Mo production rates from natural molybdenum in research reactors. Journal of Radioanalytical and Nuclear Chemistry, 311(1), 409–418. https://doi.org/10.1007/s10967-016-5036-6
Chakravarty, R., Ram, R., & Dash, A. (2014). Comparative Assessment of Nanostructured Metal Oxides: A Potential Step Forward to Develop Clinically Useful 99 Mo/ 99m Tc Generators using (n,γ) 99 Mo. Separation Science and Technology, 49(12), 1825–1837. https://doi.org/10.1080/01496395.2014.905596
Chakravarty, R., Ram, R., Mishra, R., Sen, D., Mazumder, S., Pillai, M. R. A., & Dash, A. (2013). MesopoChakravarty, R., Ram, R., Mishra, R., Sen, D., Mazumder, S., Pillai, M. R. A., & Dash, A. (2013). Mesoporous alumina (MA) based double column approach for development of a clinical scale99Mo/99mTc generator using (n,γ)99Mo: An enticing application o. Industrial and Engineering Chemistry Research, 52(33), 11673–11684. https://doi.org/10.1021/ie401042n
Damjanović, V., Pisk, J., Kuzman, D., Agustin, D., Vrdoljak, V., Stilinović, V., & Cindrić, M. (2019). The synthesis, structure and catalytic properties of the [Mo7O24 (μ-Mo 8 O 26 )Mo7O24]^16−anion formed via two intermediate heptamolybdates [Co(en)3]2[NaMo7O24]Cl·nH2O and (H3O)[Co(en)3]2[Mo7O24]Cl·9H2O. Dalton Transactions, 3–12. https://doi.org/10.1039/C9DT01625B
El-Absy, M. A., El-Amir, M. A., Fasih, T. W., Ramadan, H. E., & El-Shahat, M. F. (2014). Preparation of 99Mo/99mTc generator based on alumina 99Mo-molybdate (VI) gel. Journal of Radioanalytical and Nuclear Chemistry, 299(3), 1859–1864. https://doi.org/10.1007/s10967-014-2930-7
Guedes-Silva, C. C., Ferreira, T. dos S., Carvalho, F. M. S., Paula, C. M. de, & Otubo, L. (2016). Influence of Alumina Phases on the Molybdenum Adsorption Capacity and Chemical Stability for 99Mo/99mTc Generators Columns. Materials Research, 19(4), 791–794. https://doi.org/10.1590/1980-5373-MR-2015-0560
Jo, D., Lee, K.-H., Kim, H.-C., & Chae, H. (2014). Neutronic and thermal hydraulic analyses of LEU targets irradiated in a research reactor for Molybdenum-99 production. Annals of Nuclear Energy, 71, 467–474. https://doi.org/10.1016/j.anucene.2014.04.017
Jürgens, S., Herrmann, W. A., & Kühn, F. E. (2014). Rhenium and technetium based radiopharmaceuticals: Development and recent advances. Journal of Organometallic Chemistry, 751, 83–89. https://doi.org/10.1016/j.jorganchem.2013.07.042
Marlina, M, Sarmini, E., Herlina, H., Sriyono, S., Saptiama, I., Setiawan, H., & Kadarisman, K. (2017). Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent. Atom Indonesia, 43(1), 1. https://doi.org/10.17146/aij.2017.587
Marlina, Marlina, Sriyono, S., Lestari, E., Abidin, A., Setiawan, H., & Kadarisman, K. (2016). Desain dan Performa Prototipe Generator 99Mo/99mTc dengan Kolom Material Berbasis Zirkonium dan Kolom Alumina. Jurnal Kimia Dan Kemasan, 38(2), 93. https://doi.org/10.24817/jkk.v38i2.2703
Munir, M, Herlina, Sriyono, Sarmini, E., Abidin, Lubis, H., & Marlina. (2019). Influence of GA Siwabessy Reactor Irradiation Period on The Molybdenum-99 (99Mo) Production by Neutron Activation of Natural Molybdenum to Produce Technetium-99m (99mTc). In Journal of Physics: Conference Series (Vol. 99, pp. 1–9). https://doi.org/10.1088/1742-6596/1204/1/012021
Munir, Miftakul, Sarmini, E., Herlina, H., Pujiyanto, A., Saptiama, I., Kadarisman, K., & Kurnia, S. (2018). Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development. Jurnal Kimia Dan Kemasan, 40(2), 87. https://doi.org/10.24817/jkk.v40i2.3772
Saptiama, I., Lestari, E., Sarmini, E., Lubis, H., Marlina, M., & Mutalib, A. (2016). Development of 99Mo/99mTc Generator System for Production of Medical Radionuclide 99mTc using a Neutron-activated 99Mo and Zirconium Based Material (ZBM) as its Adsorbent. Atom Indonesia, 42(3), 115. https://doi.org/10.17146/aij.2016.531
Saptiama, I, Marlina, M., Sarmini, E., Herlina, H., Sriyono, S., Abidin, A., … Mutalib, A. (2015). The Use of Sodium Hypochlorite Solution for (n,γ) 99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM). Atom Indonesia, 41(2), 103. https://doi.org/10.17146/aij.2015.384
Saptiama, Indra, Kaneti, Y. V., Oveisi, H., Suzuki, Y., Tsuchiya, K., Takai, K., … Yamauch, Y. (2018). Molybdenum adsorption properties of alumina-embedded mesoporous silica for medical radioisotope production. Bulletin of the Chemical Society of Japan, 91(2), 195–200. https://doi.org/10.1246/bcsj.20170295
Saptiama, Indra, Kaneti, Y. V., Suzuki, Y., Suzuki, Y., Tsuchiya, K., Sakae, T., … Yamauchi, Y. (2017). Mesoporous Alumina as an Effective Adsorbent for Molybdenum (Mo) toward Instant Production of Radioisotope for Medical Use. Bulletin of the Chemical Society of Japan, 90(10), 1174–1179. https://doi.org/10.1246/bcsj.20170184
Saptiama, Indra, Kaneti, Y. V., Suzuki, Y., Tsuchiya, K., Fukumitsu, N., Sakae, T., … Yamauchi, Y. (2018). Template-Free Fabrication of Mesoporous Alumina Nanospheres Using Post-Synthesis Water-Ethanol Treatment of Monodispersed Aluminium Glycerate Nanospheres for Molybdenum Adsorption. Small, 14(21), 1800474. https://doi.org/10.1002/smll.201800474
Saptiama, Indra, Kaneti, Y. V., Yuliarto, B., Kumada, H., Tsuchiya, K., Fujita, Y., … Yamauchi, Y. (2019). Biomolecule-Assisted Synthesis of Hierarchical Multilayered Boehmite and Alumina Nanosheets for Enhanced Molybdenum Adsorption. Chemistry - A European Journal, 1–14. https://doi.org/10.1002/chem.201900177
Selivanova, S. V, Lavallée, É., Senta, H., Caouette, L., Mcewan, A. J. B., Guérin, B., … Turcotte, É. (2016). Clinical Trial Using Sodium Pertechnetate. J NucI Med, 58(5), 791–798. https://doi.org/10.2967/jnumed.116.178509
Sholikhah, U. N., Lubis, H., Sarmini, E., Herlina, H., & Wisnukaton, K. (2016). ZIRCONIUM POLYMER CHARACTERISTIC AS 99Mo / 99mTc GENERATOR ABSORBENT FOR DIAGNOSTIC RADIOPHARMACEUTICALS. Widyariset, 2(1), 17. https://doi.org/10.14203/widyariset.2.1.2016.17-26
Sulaiman, S., Sugiharto, Y., Chairuman, C., Setiawan, G., & Gunawan, A. H. (2018). OPTIMASI pH ALUMINA dan 99Mo DALAM PEMBUATAN GENERATOR 99Mo/99mTc BERBASIS MoO3 ALAM. Urania Jurnal Ilmiah Daur Bahan Bakar Nuklir, 24(2), 115–123. https://doi.org/10.17146/urania.2018.24.2.4159
Uzunov, N., Yordanova, G., Salim, S., Stancheva, N., Mineva, V., Meléndez-Alafort, L., & Rosato, A. (2018). Quality assurance of Mo-99/Tc-99m radionuclide generators. Acta Scientifica Naturalis, 5(1), 40–47. https://doi.org/10.2478/asn-2018-0006
Welsh, J., Bigles, C. I., & Valderrabano, A. (2015). Future U.S. supply of Mo-99 production through fission based LEU/LEU technology. Journal of Radioanalytical and Nuclear Chemistry, 305(1), 9–12. https://doi.org/10.1007/s10967-015-4090-9
Copyright (c) 2019 Miftakul Munir
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3)Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
