THE CORRELATION OF JOINT SPACE WIDTH WITH SYNOVIAL FLUID CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVEL IN KNEE OSTEOARTHRITIS PATIENTS
Abstrak
ABSTRAK
Osteoartritis (OA) merupakan penyakit sendi degeneratif yang berkaitan dengan kerusakan rawan sendi, dimana sendi yang paling sering terkena OA adalah vertebra, panggul, lutut dan pergelangan kaki. Patomekanisme OA meliputi berbagai etiologi yang berperan pada keseimbangan sintesis dan destruksi rawan sendi. Pemeriksaan radiolologi merupakan metode yang paling sering digunakan dalam memantau progresivitas osteoartritis, namun tidak dapat menunjukkan perubahan pada lutut akibat OA sampai dengan fase lanjut penyakit. Radiologi konvensional dapat memperkirakan ketebalan rawan sendi melalui pengukuran lebar celah sendi atau joint space width (JSW). Salah satu metode alternatif yang dapat mendeteksi perubahan sendi pada stadium dini penyakit adalah dengan pemeriksaan petanda sintesis dan degradasi jaringan. Cartilage oligomeric matrix protein (COMP) merupakan salah satu petanda destruksi rawan sendi dari golongan non-agrekan dan non-kolagen, terdapat pada rawan sendi dan jaringan lainnya. Beberapa penelitian telah melaporkan adanya hubungan antara kadar COMP (serum atau cairan sendi) dengan progresivitas radiografi pasien OA lutut. Penelitian ini bertujuan untuk menilai hubungan antara lebar celah sendi dengan kadar COMP cairan sendi pada subyek OA lutut. Penelitian deskriptif analitik dengan pendekatan cross sectional pada 69 subyek OA lutut yang berobat jalan di poliklinik reumatologi RS Wahidin Sudirohusodo Makassar dan Rumah Sakit Jejaring Pendidikan, Maret-Juni 2015. Dari penelitian ini didapatkan adanya hubungan antara lebar celah sendi dengan kadar COMP cairan sendi, dimana semakin sempit lebar celah sendi, semakin tinggi kadar COMP cairan sendi, dan hal tersebut tidak dipengaruhi oleh umur dan obesitas
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