EFEKTIVITAS EKSTRAK DAUN SIRSAK (Annona muricate Linn) TERHADAP PERUBAHAN KADAR FRAKSI LIPID PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG MENGALAMI DISLIPIDEMIA
Abstrak
Latar Belakang: Dislipidemia berhubungan dengan angka mortalitas akibat penyakit kardiovaskuler. Daun sirsak adalah obat tradisional yang dapat menurunkan kadar kolesterol darah. Studi mengenai efektivitas daun sirsak terhadap kadar kolesterol masih kurang dan mendapatkan hasil bervariasi. Tujuan: Mengetahui efek ekstrak daun sirsak (Annona muricata Linn) terhadap perubahan kadar fraksi lipid pada.Tikus jantan putih yang mengalami dislipidemia. Metode: Penelitian ini menggunakan one group pre-test post-test pada 15 ekor tikus putih jantan yang dibagi menjadi 3 kelompok. Kelompok pertama diberi ekstrak daun sirsak, kelompok kedua diberi simvastatin dan kelompok ketiga diberi placebo. Hasil: Pada awal penelitian, pada kelompok tikus yang mendapat ekstrak Annona muricata, rerata kadar kolesterol total adalah 188,4 mg/dL, trigliserida 107,4 mg/dl, LDL 94 mg/dl, dan HDL 24,8 mg/dl. Setelah perlakuan didapatkan rata rata kadar kolesterol total 136,2 mg/dL (p=0.023), trigliserida 90,4 mg/dL (p=0.018), LDL 81 mg/dL (p=0.000), HDL 28.8 mg/dL (p=0.02). Kesimpulan: Ekstrak daun Annona muricata L dapat menurunkan secara signifikan kadar kolesterol total, kolesterol LDL, dan trigliserida, serta juga dapat meningkatkan kadar kolesterol HDL pada kelompok tikus hiperkolesteromia yang diinduksi oleh diet.
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