THE  POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD  GLUCOSE LOWERING AGENT : A REVIEW

Dwi Wahyuni Leboe; Nur Syamsi Dhuha; Munifah Wahyuddin; Nur Rezky Rutami A

doi:10.24252/kesehatan.v1i1.18181

Dwi Wahyuni Leboe UIN ALAUDDIN MAKASSAR
Nur Syamsi Dhuha UIN ALAUDDIN MAKASSAR
Munifah Wahyuddin UIN ALAUDDIN MAKASSAR
Nur Rezky Rutami A

DOI: https://doi.org/10.24252/kesehatan.v1i1.18181

Abstract

The increasing mortality rate in Indonesia due to diabetes mellitus is a health problem in the world, especially in Indonesian. Evidenced by prevalence of diabetes mellitus which increases every year and is estimated in 2030 achieved 21,3 million according by WHO. Pharmacological therapy which cost is relatively expensive and can caused side effects from the use of chemical drugs. For this reason, the importance of finding new alternative therapy. Sorghum bicolor L. is a cereal that has high nutritional value and phytochemical compounds. This research purpose to know contain of Sorghum bicolor L. and the mechanisme Sorghum bicolor L. as a blood glucose lowering agent. In this research is the literature study method based on primary and secondary data obtained. The database obtained is from Google scholar, Science direct, Research gate, NCBI, MDPI by using keywords. And the analysis of 43 journals obtained were scanned and analyzed in more detail by introduction, method, result, and conclusion of each journal . And the made in the data analysis table. Shows that Sorghum bicolor L. can be used as a blood glucose lowering agent because contain antidiabetic compounds, namely is phenolic compounds of phenolic acid, flavanoids, and tannin. And has a low glycemic index value and high fiber. Which can provide hypoglycemic effects and reduce postprandial blood glucose levels because it a slor digestion, slow gastric emptying, can inhibit the activity of digestive enzymes, namely the activity of α-glucosidase and α- amylase, increasen insulin sensitivity, and inhibits the process of glucogenesis in the liverblood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs.

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References

Afify, A. E., El-beltagi, H. S., El-salam, S. M. A., & Omran, A. A. (2012). Biochemical changes in phenols , flavonoids , tannins , vitamin E , 毬 -carotene and antioxidant activity during soaking of three white sorghum varieties. 2(3), 203–209. https://doi.org/10.1016/S2221-1691(12)60042-2

Ah Cabrera-ramírez. (2020). Sorghum : An Important Source of Bioactive Compounds. 125–126. https://doi.org/10.34297/AJBSR.2020.08.001253.Received

Ahyar, H., Maret, U. S., Andriani, H., Sukmana, D. J., & Mada, U. G. (2020). Buku Metode Penelitian Kualitatif & Kuantitatif.

Althwab, S., Carr, T. P., Weller, C. L., Dweikat, I. M., & Schlegel, V. (2015). Advances in grain sorghum and its co-products as a human health promoting dietary system.

Ambati, K., & Sucharitha, K. V. (2019). Review Article Millets-Review On Nutritional Profiles And Health Benefits. 10(I), 33943–33948. https://doi.org/10.24327/IJRSR

Anunciação, P. C., Cardoso, L. de M., Gomes, J. V. P., Della Lucia, C. M., Carvalho, C. W. P., Galdeano, M. C., … Pinheiro-Sant’Ana, H. M. (2017). Comparing sorghum and wheat whole grain breakfast cereals: Sensorial acceptance and bioactive compound content. Food Chemistry, 221, 984–989. https://doi.org/10.1016/j.foodchem.2016.11.065

Ashfiyah, V. N. (2019). Substitusi Sorgum Dan Ubi Jalar Putih Pada Roti Bagel Substitution of Sorghum and White Sweet Potato on Bagels an Alternative Snack for Diabetics. 14(1), 75–86.

Belarbi, M.-, & Gaouar, N.-. (2013). Antioxidant activity and nutrient composition of sorghum bicolor l . And secale cereale l . In algeria. 3(5), 1–12.

Cani, D., Neyrinck, A. M., & Meheust, A. (2010). B ritish J ournal of N utrition. British Journal of Nutrition, 104(2), 1–51.

chavez davy. (2018). Artículo de Revisión / Review Article. 45(2), 169–177.

Cristine, P., Leandro, A., Cardoso, D. M., Aparecida, V., & Queiroz, V. (2018). Consumption of a drink containing extruded sorghum reduces glycaemic response of the subsequent meal. European Journal of Nutrition, 57(1), 251–257. https://doi.org/10.1007/s00394-016-1314-x

Cristine, P., Morais, L. De, Cássia, R. De, Alfenas, G., Aparecida, V., Queiroz, V., … Ana, P. (2019). Extruded sorghum consumption associated with a caloric restricted diet reduces body fat in overweight men : A randomized controlled trial. Food Research International, 119(October 2018), 693–700. https://doi.org/10.1016/j.foodres.2018.10.048

D, M. L. S. P., & D, J. P. Z. P. (2018). Postprandial glucose and insulin response to a high-fiber muffin top containing resistant starch type 4 in healthy adults : a double-blind , randomized , controlled trial. Nutrition, 53, 59–63. https://doi.org/10.1016/j.nut.2018.01.002

Ekta, S. (2016). The Pharma Innovation Journal 2016; 5(8): 42-46 Millet’s anti-nutrients and their therapeutic effects. 5(8), 42–46. Retrieved from http://ww.slideshare.net/poshadri/cereals-millet-processing,

Emblica, P., Mencit, L. P., Yang, B. C., & Induksi, D. I. (2019). Journal of Vocational Health Studies. 03, 53–58. https://doi.org/10.20473/jvhs.V3I2.2019.53

Fathurrizqiah. (2015). of Nutrition College , Volume Halaman of Nutrition College , Volume Halaman Online di : http://ejournal-s1.undip.ac.id/index.php/jnc Journal of Nutrition College , Volume 4 , Nomor 2 , Tahun 2015. 4.

Gani, A., Sm, W., Fa, M., & Hameed, G. (2012). Whole-Grain Cereal Bioactive Compounds and Their Health Benefits : A Review. 3(3). https://doi.org/10.4172/2157-7110.1000146

Gu, X. (2014). Effects of Grain Sorghum Muffin on Blood Glucose and Insulin Responses in Prediabetic Men.

Himanshu. (2018). Nutritional and Nutraceutical Properties of Millets : 1(1), 1–10.

Id, L. T., Fredrich, C., Pinto, D., & Kessler, A. D. M. (2019). Effect of partial substitution of rice with sorghum and inclusion of hydrolyzable tannins on digestibility and postprandial glycemia in adult dogs. 1–14.

Isdamayani Linda, B. P. (2015). of Nutrition College , Volume Halaman of Nutrition College Online di : http://ejournal-s1.undip.ac.id/index.php/jnc. 4.

Isnaini, N., & Ratnasari, R. (2018). Faktor risiko mempengaruhi kejadian Diabetes mellitus tipe dua. Jurnal Kebidanan Dan Keperawatan Aisyiyah, 14(1), 59–68. https://doi.org/10.31101/jkk.550

Kam, J., Puranik, S., Yadav, R., Manwaring, H. R., Pierre, S., Srivastava, R. K., … Vasconcelos, M. W. (2016). Dietary Interventions for Type 2 Diabetes : How Millet Comes to Help. 7(September), 1–14. https://doi.org/10.3389/fpls.2016.01454

Khan, I., Yousif, A. M., Johnson, S. K., & Gamlath, S. (2014). Acute effect of sorghum flour-containing pasta on plasma total polyphenols, antioxidant capacity and oxidative stress markers in healthy subjects: A randomised controlled trial. Clinical Nutrition, 1–7. https://doi.org/10.1016/j.clnu.2014.08.005

Kim, J., & Park, Y. (2012). Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats. 1–7.

Kim, J. S., Hyun, T. K., & Kim, M. J. (2011). The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities. Food Chemistry, 124(4), 1647–1651. https://doi.org/10.1016/j.foodchem.2010.08.020

Lemlioglu-austin, D., Turner, N. D., & Mcdonough, C. M. (2012). Effects of Sorghum [Sorghum bicolor (L.) Moench] Crude Extracts on Starch Digestibility, Estimated Glycemic Index (EGI), and Resistant Starch (RS) Contents of Porridges. 11124–11138. https://doi.org/10.3390/molecules170911124

Mkandawire, N. L., Kaufman, R. C., Bean, S. R., Weller, C. L., Jackson, D. S., & Rose, D. J. (2013). E ff ects of Sorghum ( Sorghum bicolor (L.) Moench) Tannins on α ‑ Amylase Activity and in Vitro Digestibility of Starch in Raw and Processed Flours.

Ners, J. (2018). pengaruh pemberian rebusan daun kelor terhadap kadar gula darah pada penderita dm tipe 2 di kelurahan bangkinang kota wilayah kerja puskesmas tahun 2017 Yenny Safitri BAB I. 2, 43–50.

Ningtiyas, E. N., Widyaningsih, T. D., & Sutrisno, A. (2019). Optimization of the Formulation of Antidiabetic Functional Drinks According to Sorghum , Red Ginger , and Aromatic Pandan Leaves in Type II Diabetes Rats. 4(3), 445–451.

Ofosu, F. K., Elahi, F., Daliri, E. B., Chelliah, R., Ham, H. J., Kim, J., … Oh, D. (n.d.). Potential Exerted by Millet Grain Varieties. 1–14.

Park, J. H., Lee, S. H., Chung, I. M., & Park, Y. (2012). Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet. Nutrition Research and Practice, 6(4), 322–327. https://doi.org/10.4162/nrp.2012.6.4.322

Rainier Requel. (2019). Starch digestibility and sensory acceptance of gluten free foods prepared with tannin sorghum flour. https://doi.org/10.1590/S1678-3921.pab2019.v54.01205

Ramatoulaye, F., Mady, C., Fallou, S., Amadou, K., Cyril, D., & Massamba, D. (2016). Production and Use Sorghum : A Literature Review. 2–5.

Salazar-lópez, N. J., González-aguilar, G. A., Rouzaud-, O., Loarca-piña, G., Gorinstein, S., Robles-sánchez, M., … Sorghum, M. R. (2020). Sorghum bran supplementation ameliorates dyslipidemia , glucose dysregulation , inflammation and stress oxidative induced by a high-fat diet in rats. CyTA - Journal of Food, 18(1), 20–30. https://doi.org/10.1080/19476337.2019.1702105

Shiekuma, S., Ukeyima, M., Ahuah, J., & Blessing, I. (2019). Effect of Sorghum-tigernut Ibyer ( A Traditional Gruel ) on the Fasting Blood Glucose Levels of Alloxan-induced Diabetic Rats Effect of Sorghum-tigernut Ibyer (A Traditional Gruel ) on the Fasting Blood Glucose Levels of Alloxan-induced Diabetic Rats. (June). https://doi.org/10.9734/ejnfs/2019/v9i330065

Singh, E. (2016). Potential of Millets : Nutrients Composition and Health Benefits. 5(2), 46–50.

Stefoska-needham, A., Beck, E., & Johnson, S. K. (2015). Sorghum : an underutilized cereal whole grain with the potential to assist in the prevention of chronic disease. 31, 401–437.

suarni. (2016). Peranan Sifat Fisikokimia Sorgum Dalam Diversifikasi Pangan Dan Industri Serta Prospek Pengembangannya Role of Sorghum Physicochemical Properties in Food Diversification and Industry and Its Development Prospect. https://doi.org/10.21082/jp3.v35n3.2016.p99-110

Taylor, P., Moraiscardoso, L. De, Pinheiro, S. S., Stampini, H., Martino, D., & Ana, M. P. (n.d.). Critical Reviews in Food Science and Nutrition Sorghum ( sorghum bicolor l .): Nutrients , Bioactive Compounds , and Potential Impact on Human Health. (April 2015), 37–41. https://doi.org/10.1080/10408398.2014.887057

Vu, P. N., Dung, V., & Tian, B. (2014). Antithrombotic and antidiabetic flavonoid glycosides from the grains of Sorghum bicolor ( L .) Moench var . hwanggeumchal. 1394–1402. https://doi.org/10.1007/s12272-014-0422-5

Wolter, A., Hager, A., Zannini, E., & Arendt, E. K. (2013). In vitro starch digestibility and predicted glycaemic indexes of buckwheat , oat , quinoa , sorghum , teff and commercial gluten-free bread. Journal of Cereal Science, 1–6. https://doi.org/10.1016/j.jcs.2013.09.003

Xiong, Y., Zhang, P., Warner, R. D., & Fang, Z. (2019). Sorghum Grain : From Genotype , Nutrition , and Phenolic Profile to Its Health Benefits and Food Applications. 18, 2025–2046. https://doi.org/10.1111/1541-4337.12506