Efficacy of Petai (Parkia speciosa, HASSK) leaf extract as an antidyslipidemic herb in Rattus norvegicus induced by high-fat feed
Abstract
This study aims to analyze the effect of Petai (Parkia speciosa, HASSK) leaf extract on total cholesterol, triglycerides, LDL and HDL levels in dyslipidemic rat models induced high-fat feed. The pre and post-test with control group design using 30 rats were divided into 5 groups, namely positive, normal, and Petai leaf extract at doses of 100, 200 and 400 mg/kg BW. All rats were fed high fat diet for 14 days. The extract group was given Petai leaf extract orally from day 14 to day 28. Lipid profiles were tested using enzymatic spectrophotometry method. Petai leaf extract was identified to contain flavonoid compounds. The research showed that the Petai leaf extract at a dose of 100, 200 and 400 mg / kg BW were able to decrease total cholesterol: (-32.06 ± 3.63), (-47.23 ± 2.98), and (-49,18 ± 2.66), mg / dL; triglyceride: (-11.12 ± 3.99), (-37.31 ± 0.65), and (-43.01 ± 1.17) mg / dL; LDL: (-17.14 ± 9.30), (-46.51 ± 1.99), and (-46.51 ± 1.99) mg / dL; and increasing HDL levels: (6.44 ± 0.21), (8.42 ± 0.73), and (12.1 ± 0.43) mg / dL respectively. This study proves that Petai leaf extract has anti-dyslipidemic activity in rat models by reducing total cholesterol, triglycerides, and LDL and increasing HDL levels.
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References
Butarbutar, R. H., Robiyanto, R., & Untari, E. K. (2016). Potensi Ekstrak Etanol Daun Petai (Parkia speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (SOD) pada Plasma Tikus yang Mengalami Stres Oksidatif. Pharmaceutical Sciences and Research, 3(2), 97–106. doi:DOI: 10.7454/psr.v3i3.3539
Cheng, M.-C., Ker, Y.-B., Yu, T.-H., Lin, L.-Y., Peng, R. Y., & Peng, C.-H. (2010). Chemical synthesis of 9(Z)-octadecenamide and its hypolipidemic effect: a bioactive agent found in the essential oil of mountain celery seeds. J Agric Food Chem. 2010; 58(3):. Journal of Agriculture Food Chemistry, 58(3), 1502–8.
Dewi, I. P., & Merry, M. S. (2017). Peranan Obat Golongan Statin. Berkala Ilmiah Kedokteran Duta Wacana, 2(3), 1. doi:DOI: 10.21460/bikdw.v2i3.75
Donald W. Miller, J. M. (2015). Fallacies in Modern Medicine: the HIV/AIDS Hypothesis. Journal of American Physicians and Surgeons, 20(1), 18-19.
Feingold, K. R., & Grunfeld, C. (2000). Introduction to Lipids and Lipoproteins. In B.-P. P. De Groot LJ, Endotext. South Dartmouth (MA).
González-Castejón, M., García-Carrasco, B., Fernández-Dacosta, R., Dávalos, A., & Rodriguez-Casado, A. (2013). Reduction of adipogenesis and lipid accumulation by Taraxacum officinale (Dandelion) extracts in 3T3L1 adipocytes: an in vitro study. Phytotheraphy Research, 28(5), 745-52. doi:DOI: 10.1002/ptr.5059
Gunawan, H., Sitorus, P., & Rosidah. (2018). Pengaruh Pemberian Ekstrak Etanol Herba Poguntano (Picria FelTerrae Lour.) Terhadap Profil Lipid Tikus Putih Jantan Dislipidemia. Talenta Conference Series: Tropical Medicine (TM), 1(1), 230–236. doi:DOI: 10.32734/tm/v1i1.81
Ji, X., Shi, S., Liu, B., Shan, M., Tang, D., Zhang, W., . . . Wang, Y. (2019). Review Bioactive compounds from herbal medicines to manage dyslipidemia. Biomedicine & Pharmacotherapy, 118, 109338. doi:DOI: 10.1016/j.biopha.2019.109338
Kanbur, M., Eraslan, G., Sarıca, Z. S., & ÖznurAslan. (2011). The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice. Food and Chemical Toxicology, 49(9), 1960-1964. doi:DOI: 10.1016/j.fct.2011.05.006
Kementerian Kesehatan. (2013). RISKESDAS.
Kusumawati, D. (2004). Bersahabat dengan Hewan Coba. Yogyakarta: Gajah Mada University Press.
Monika, A. P., & Lestariana, W. (2014). Pengaruh Pemberian Kombinasi Kuersetin Dan Glibenklamid Terhadap Kadar Kolesterol LDL Pada Tikus Diabetes Melitus Tipe 2. Jurnal Kedokteran Dan Kesehatan Indonesia, 6(1), 28-37. doi:DOI: 10.20885/jkki.vol6.iss1.art5
Nichols, J. (2003). The Laboratory Ray. Florida Atlantic University.
Perhimpunan Endokrinologi Indonesia. (2019). Panduan Pedoman Pengelolaan Dislipidemia di Indonesia tahun 2019. PB Perkeni.
Romdhoni, M. F. (2014). Studi Farmakodinamik Ekstrak Etanol Akar Seledri (Apium graveolens) Terhadap Profil Lipid dan Apo-A1 Serum Tikus Putih Stain Wistar (Rattus Novergicus Strain Wistar) Dislipidemia. Thesis, Universitas Airlangga, Surabaya. doi:http://repository.unair.ac.id/id/eprint/39223
Rouhi-Boroujeni, H., Rouhi-Boroujeni, H., Heidarian, E., Mohammadizadeh, F., & Rafieian-Kopaei, M. (2015). Herbs with anti-lipid effects and their interactions with statins as a chemical anti- hyperlipidemia group drugs: A systematic review. ARYA Atherosclerosis, 11(4), 244-51.
Suzuki, R., Tanaka, M., Takanashi, M., Hussain, A., Yuan, B., Toyoda, H., & Kuroda, M. (2011). Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. Nutr Metab (Lond) 2011;8:14. Nutrition & Metabolism, 8(14). doi:DOI: 10.1186/1743-7075-8-14
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