Efek Minyak Zaitun terhadap Kadar Glukosa Darah Puasa dan Kadar Growth Differentiation Factor-15 (GDF-15) pada Tikus Model Diabetes
Abstrak
Minyak zaitun mengandung antioksidan tinggi dan telah banyak diteliti pengaruhnya terhadap diabetes mellitus (DM), tetapi belum ada penelitian sebelumnya yang meneliti tentang efek minyak zaitun terhadap kadar Growth Differentiation Factor-15 (GDF-15) yang kadarnya meningkat pada kondisi inflamasi. Penelitian ini bertujuan untuk melihat efek minyak zaitun terhadap berat badan, kadar glukosa darah puasa serta kadar GDF-15 pada DM tipe 1 dan tipe 2. Penelitian ini merupakan penelitian eksperimental dengan pendekatan Pre and Post-Test Control Group Design menggunakan 12 tikus yang dibagi dalam 3 kelompok yakni kelompok I atau kelompok kontrol diabetes DM I dan DM II, kelompok II atau kelompok tikus model DM I, dan kelompok III atau kelompok tikus model DM II. Hasil penelitian didapatkan terdapat perubahan berat badan yang signifikan dalam kelompok kontrol dan DM II sebelum dan setelah intervensi (p= 0,028 dan p= 0,018). Untuk kadar glukosa darah puasa terdapat perbedaan yang signifikan sebelum dan setelah intervensi pada kelompok kontrol, kelompok DM I dan DM II ( masing-masing nilai p= 0,002; 0,019; 0,034). Sementara kadar GDF-15 kelompok DM II mengalami penurunan yang signifikan setelah intervensi (p= 0,016). Sehingga dapat disimpulkan bahwa pemberian minyak zaitun dapat mempengaruhi berat badan dan kadar GFD-15 pada tikus model DM tipe 2 dan dapat menurunkan kadar glukosa darah puasa pada tikus model DM tipe I dan DM tipe II.
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