UJI EFEK PENYEMBUHAN LUKA SAYAT EKSTRAK ETANOL DAUN KECOMBRANG (Etlingera elatior) DALAM BENTUK SEDIAAN GEL TERHADAP KELINCI (Oryctolagus cuniculus)
Abstract
Has done research on Wound Healing Cut Effects of Ethanol Extract Leaf kecombrang (Etlingera elatior) In Categories Gel Against Rabbit (Oryctolagus cuniculus). The aim was to evaluate the efficacy and the optimum concentration of the extract healing cuts kecombrang (Etlingera elatior) in a gel dosage form. Variants concentration used was 5%, 7%, and 9%. The method used is the sample extraction by maceration and wound gel is made in 3 concentrations of 5%, 7%, and 9%. In addition it is also used as a negative control base gel and gel Bioplacenton® as a positive control, then back skin of rabbits (Oryctolagus cuniculus) were wounded using a scalpel.
Results of statistical analysis using the method Annova completely randomized design showed that the leaf gel preparations kecombrang (Etlingera elatior) may decrease and cuts heal in rabbits with a concentration of 9% which shows the effect of healing the most effective cuts.
References
Ansel, Howard C. Pengantar Bentuk Sediaan Farmasi. Jakarta: UI Press. . 2008.
Berman, Audrey. Buku Ajar Praktik Keperawatan Klinis Edisi Kelima. Jakarta: EGC: Penerbit Buku Kedokteran. 2009.
Corwin, Elizabeth J. Buku Saku Patofisiologi. Jakarta: Penerbit Buku Kedokteran. 2009.
Lachman L., Liberman HA & Kaning JL. Teori dan Praktek Farmasi Industri Edisi Ketiga. Jakarta: Penerbit Universitas Indonesia. 2007.
Ningtyas, Rina. ‘Uji Antioksidant dan Antibakteri Ekstrak Air Daun Kecombrang (Etlingera elatior (Jack) R.M. Smith’.Jakarta: UIN Syarif Hidayatullah. 2010. Hal:9-10.
Pusponegoro AD. Luka Dalam Buku Ajar Ilmu Bedah Edisi ke-2. Jakarta: EGC, Penyunting: Sjamsuhidajat R, De Jong W. 2005.
Pearce, Evelyn C. Anatomi Dan Fisiologi Untuk Paramedis. Jakarta: PT Gramedia Pustaka Utama. 2009.
Robins dan Cotwan. Buku Saku Dasar Patologis Penyakit. Jakarta: EGC: Penerbit Buku Kedokteran. 2009.
Rowe, Raymond C., Paul JS, Marian EQ. Handbook of Pharmaceutical Exipients Sixth Edition. The Pharmaceutical Press. USA. 2009.
Voight, Rudolf. Buku Pelajaran Teknologi Farmasi. Yogyakarta: Gadjah Mada University Press. 1995