STANDARDISASI  MUTU FISIK EKSTRAK ETANOL DAUN SAWO MANILA (Manilkara zapota L.) DAN UJI POTENSI ANTIBAKTERI TERHADAP E.coli

A. Tenriugi Daeng Pine; Yuyun Sri Wahyuni; Nirmala Nirmala; A. Tenri Muji

doi:10.24252/kesehatan.v0i0.12816

A. Tenriugi Daeng Pine Akademi Farmasi Yamasi Makassar
(ID)
Yuyun Sri Wahyuni Akademi Farmasi Yamasi Makassar
Nirmala Nirmala Akademi Farmasi Yamasi Makassar
A. Tenri Muji Akademi Farmasi Yamasi Makassar

DOI: https://doi.org/10.24252/kesehatan.v0i0.12816

Abstract

Quality inspection and standardization of traditional medicine raw materials is an important as the begining of standardization of traditional medicines. This study aims to determine specific and nonspecific parameters physical standardization and to determinae any potential of sapodilla leaves (Manilkara zapota L.) ethanol extract as an antibacterial against E.coli. Simplisia of sapodilla leaf (Manilkara zapota L.) collected from Manjalling Village, West Bajeng District, Gowa Regency. Simplisia was extracted to produce thick extraxt by maceration using ethanol 96% as solvent. The thick extract, then tested for specific parameters (identity, organoleptic), nonspecific (shrinkage drying) and its activity as an antibacterial against E.coli through paperdisc method. The results of this study showed that organoleptically the extract produced was thick extract with a distinctive blackish-green (dark green) color, and bitter taste. Confirmed Identification of the plant name is Sapodilla (Manilkara zapota L.) known as sawo manilla in the local terms. The results for non-specific parameters by testing the drying shrinkage levels are an average of 79.5488%. this process aimed to provide maximum limits on the amount of compound lost in the drying process. The results for antibacterial activity against E. coli gained in extract concentration of 10% w/v with 11 mm inhibition zone

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References

BPOM (2000) Parameter Standar Umum Ekstrak Tumbuhan Obat. Indonesia: Direktorat Jenderal Pengawasan Obat dan Makanan.

BPOM (2014) Peraturan Kepala BPOM RI Nomor 12 Tahun 2014 Tentang Persyaratan Mutu Obat Tradisional, BPOM RI. Jakarta.

Hemayet Hossain, M. et al. (2012) ‘Evaluation of Anti-inflammatory Activity and Total Flavonoids Content of Manilkara zapota (Linn.) Bark’, International Journal of Pharmaceutical and Phytopharmacological Research Int.J.Pharm.Phytopharmacol.Res, 35(21), pp. 2249–6084.

Mufti, N., Bahar, E. and Arisanti, D. (2017) ‘Uji Daya Hambat Ekstrak Daun Sawo terhadap Bakteri Escherichia coli secara In Vitro’, Jurnal Kesehatan Andalas, 6(2), pp. 289–294.

Mukhriani, Nurlina, Baso, F. F. (2014) ‘Uji Aktivitas Antimikroba Dan Identifikasi Ekstrak Buah Sawo Manila (Achras Zapota L.) Terhadap Beberapa Mikroba Patogen Dengan Metode Difusi Agar.’, Jf Fik Uinam, 2(2), p. 69.

Ningrum, H. P., Yeni, L. F. and Ariyati, E. (2011) ‘Uji Daya Antibakteri Ekstrak Sawo Manila Terhadap E.coli dan Implementasinya dalam Pembelajaran Peranan Bakteri’, pp. 1–17.

Ratnani, R. D. et al. (2015) ‘Standarisasi Spesifik dan Non Spesifik Ekstraksi Hidrotropi Andrographolid Dari Sambiloto (Andrographis paniculata)’, Prosiding Seminar Nasional Peluang Herbal Sebagai Alternatif Medicine, pp. 147–155.