INVESTIGATION OF DRUG-RELATED PROBLEMS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH MACROVASCULAR COMPLICATIONS: A CROSS-SECTIONAL STUDY

  • Alifia Putri Febrianty Universitas Islam Negeri Alauddin Makassar
    (ID)

Abstract

Objective this study to identify and classify DRPs in type 2 diabetes mellitus patients with macrovascular complications. Method A cross-sectional observational study was conducted in type 2 diabetes mellitus outpatients with macrovascular complications at Makassar Regional Hospital, for two months (July and August 2018). The study complied with all clinical research requirements in accordance with the Declaration of Helsinki. Ethics committee approval was obtained from UIN Alauddin Makassar. Thirty eight prescriptions were collected for this study. Samples were recruited based on inclusion and exclusion criteria. The identification and classification of DRPs were according to the PCNE tool v 8.02. Result: The most common drug-related problems were adverse drug reactions (n = 73; 77.7%) of the therapeutic safety domain, followed by optimal therapeutic effects (n = 15; 15.9%) of the effectiveness domain and finally unneeded drugs therapy (n = 4; 4.3%) from other domains. The highest cause of DRPs was the required of drug information was not available (n = 73; 77.7%), followed by drugs not in accordance with the guidelines (n = 10; 10.6%). The results of identification and causes of DRPs obtained 101 causes of DRPs in T2DM patients with macrovascular complications. Interventions that have been made by pharmacists to doctors in the form of providing information, interventions given to patients in the form of giving drug counseling and providing interventions on drugs in the form of drug replacement and drug dosage and stopping drugs. The implementation of the intervention given by the pharmacist was well received but the implementation was not known to be the highest, at 58.8%. The status of the PTO intervention by the pharmacist was unknown because patients were outpatients at 58.8%.  Conclusion: Pharmacists have identified and categorized DRPs that occur in T2DM patients with macrovascular complications in the form of potential problems that are adverse drug reactions (may) occur as well as problems that have occurred namely the effect of suboptimal drug therapy, unnecessary drug therapy and symptoms or indications that are not treated.

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Author Biography

Alifia Putri Febrianty, Universitas Islam Negeri Alauddin Makassar

References

ADA. (2018) American Diabetes Association. Diabetes Care. Standards of Medical Care in

Diabetes.

Adusumilli., Adepu, R. “Drug related problems: an over view of various classificaton systems”. Asian Journal of Pharmaceutical and Clinical Research, 7(4), 7–10. 2014.

Ahmad, A., Mast, M. R., Nijpels, G., Elders, P. J., Dekker, J. M., & Hugtenburg, J. G. (2014) “Identification of drug-related problems of elderly patients discharged from hospital”. Patient Preference and Adherence, 8, 155–165. https://doi.org/10.2147/PPA.S48357

Bowen, A. (2016) National Clinical Guideline for Stroke Fifth Edition. Royal College of Physicians: London.

Chakraborty, N. (2016). A Study on Complication of Type 2 Diabetes Mellitus in a Diabetes Clinic of a Tertiary Care Hospital. Kolkata, West Bengal: India. 2016.

Chawla, A., Chawla, R., & Jaggi, S. (2016) “Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum”. Indian Journal of Endocrinology and Metabolism, 20(4), 546. https://doi.org/10.4103/2230-8210.183480

Dahlan, M. S. (2016). Besar Sampel Dalam Penelitian Kedokteran dan Kesehatan. Jakarta: Epidemologi Indonesia, 19.

Dimitrow, M. (2016). Development and Validation of a Drug-Related Problem Risk Assessment Tool for Use by Practical Nurses Working with Community- Dwelling Aged. Helsinki: Clinical Group.

Dipiro, Joseph T dkk. (2016). Pharmacotherapy Handbook Tenth Edition. New York: Medical, 3211-3273.

Espuny, J. L., Gonzalez-Henares, M. A., (2017). Queralt-Tomas, M. L. L., Campo-Tamayo, W., Muria-Subirats, E., Panisello-Tafalla, A., & Lucas-Noll, J. “Mortality and Cardiovascular Complications in Older Complex Chronic Patients with Type 2 Diabetes”. BioMed Research Internationalesearch International. https://doi.org/10.1155/2017/6078498

Gara, P., Varghese, G. M., Arun, J., & Nanjwade, B. K..(2016) ” A Prospective Study on Prescribing Pattern and Drug- Interactions in Type 2 Diabetes Patients With Comorbid Cardio Complications in a Teaching”. World Journal of Pharmacy and Pharmaceutical Sciences, 5(5), 1115–1132. https://doi.org/10.20959/wjpps20165-6690

Ighodaro & Am, A. (2017). “Vascular Complications in diabetes mellitus”. The New England Journal of Medicine, 1–3.

International Diabetes Federation. (2017). IDF Diabetes Atlas Sixth Edition. 2017.

International Diabetes Federation. (2017). Clinical Practice Recommendations for managing Type 2 Diabetes in Primary Care, 4-9.

Koyra, H. C. (2017). Epidemiology and Predictor of Drug Therapy Problems among Type 2 Diabetic Patients at Wolaita Soddo. Science & Education Publishing: Southern Ethiopia.

Mirghani, H. (2018). “The association of polypharmacy to diabetes distress among patients with type 2 diabetes mellitus attending an outpatient clinic in Omdurman-Sudan”. Pan African Medical Journal, 29, 1–7. https://doi.org/10.11604/pamj.2018.29.108.13863

Moayyedi, P. (2017). ACG and CAG Clinical Guideline: Management of Dyspepsia. American College of Gastroenterology: America.

Movva, R., Jampani, A., Nathani, J., Pinnamaneni, S., & Challa, S. (2015). “A prospective study of incidence of medication-related problems in general medicine ward of a tertiary care hospital”. Journal of Advanced Pharmaceutical Technology and Research, 6(4), 190. https://doi.org/10.4103/2231-4040.166502

PERKENI. (2015). Konsensus Pengendalian dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. Perkeni. https://doi.org/10.1017/CBO9781107415324.004

Rasalam, R. (2017). Antimicrobial Management of Diabetic Foot Infection. Diabetes & Primary Care: Australia.

Redzuan, R. (2017). Drug-Related Problems in Hypertensive Patients with Multiple Comorbidities. Medwin Publishers: Malaysia.

SEMDSA Guideline Committee. (2017). Guidelines for the Management of Type 2 diabetes mellitus. Jemdsa, 22(1).

Siswanto. (2015). Metodologi Penelitian Kesehatan dan Kedokteran. Yogyakarta: Bursa Ilmu.

Van Mil, J., Horvat, N., & Westerlund, T. (2017). The PCNE Classification V 8.01. Pharmaceutical Care Network Europe Foundation.

Yashkin, A. (2017). Mortality and Macrovascular Risk in Elderly With Hypertention and Diabetes: Effect of Intensive Drug Therapy. Journal of Hypertention: American. 2017.

Zazuli, Z., Rohaya, A., & Adnyana, I. K. (2017). “Drug-related problems in Type 2 diabetic patients with hypertension in Cimahi, West Java, Indonesia: A prospective study”. International Journal of Green Pharmacy, 11, S298–S304.

Published
2020-04-25
Abstract viewed = 773 times