EVALUATION OF COVID-19 VACCINE EFFECTIVENESS AMONG HEALTHCARE WORKERS USING CASCADE ANALYSIS

  • Bambang Subakti Zulkarnain Airlangga University
    (ID)
  • Eunice Marlene Sicilia Kundiman Airlangga University
    (ID)
  • Lily Aina Airlangga University
    (ID)
  • Nanda Ardianto Airlangga University
    (ID)
  • Fauzul Meiliani Airlangga University
    (ID)
  • Melinda Putri Amelia Rachman Airlangga University
    (ID)
  • Fatimatuz Zahra Oviary Satryo Airlangga University
    (ID)
  • Pharmasinta Putri Hapsari Airlangga University
    (ID)
  • Arina Dery Puspitasari Airlangga University
    (ID)
  • Alfian Nur Rosyid Airlangga University Hospital
    (ID)
  • Tamara nUR Budiarti Airlangga University
    (ID)
Keywords: Covid-19, Healthcare worker, vaccination

Abstract

Background: Healthcare workers in Indonesia have been prioritized for vaccination. Nevertheless, fully vaccinated healthcare workers are still at risk of being infected with COVID-19, but will be less likely to develop severe symptoms, be hospitalized or be at risk for death as compared to those who have not been vaccinated. Objectives: This study aims to analyze the incidence of COVID-19 in fully vaccinated healthcare workers. Methods: This cross-sectional study was conducted in 2021. All healthcare workers who have been fully vaccinated, have recovered from COVID-19 (2-4 weeks after vaccination) and able to complete a questionnaire were the participants. The collected data was then analyzed using the cascade method. Results: Based on the 529 collected questionnaires, by using the cascade analysis conclude that the percentage of healthcare workers who have been fully vaccinated was 99%, healthcare workers who have been fully vaccinated and then infected with COVID-19 was 14%, healthcare workers who have been fully vaccinated, infected with COVID-19 and hospitalized was 4%, healthcare workers who have been fully vaccinated, exposed to COVID-19, hospitalized and experienced the long-haul effect of COVID-19 was 0%. Discussion: Health workers are still at risk of being confirmed by COVID-19, because have high risk of being exposed in the workplace. The risk of being confirmed and severity are also influenced by age, gender and comorbidities. Conclusions: Complete vaccinations of healthcare workers did not reduce their risk of being infected with COVID-19, however, it can reduce the severity and the risk of the long-haul effects.

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Author Biographies

Bambang Subakti Zulkarnain, Airlangga University

Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Eunice Marlene Sicilia Kundiman, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Lily Aina, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Nanda Ardianto, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Fauzul Meiliani, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Melinda Putri Amelia Rachman, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Fatimatuz Zahra Oviary Satryo, Airlangga University

Magister of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Pharmasinta Putri Hapsari, Airlangga University

Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia

Arina Dery Puspitasari, Airlangga University

Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, Indonesia; Universitas Airlangga Hospital, Surabaya, East Java, Indonesia

Alfian Nur Rosyid, Airlangga University Hospital

Universitas Airlangga Hospital, Surabaya, East Java, Indonesia; Department of Pulmonary and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia

Tamara nUR Budiarti, Airlangga University

Public Health Master Program, Faculty of Public Health, Universitas Airlangga, Surabaya, East Java, Indonesia

References

Antonelli, M., Penfold, R. S., Merino, J., Sudre, C. H., Molteni, E., Berry, S., Canas, L. S., Graham, M. S., Klaser, K., & Modat, M. (2021). Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study. The Lancet Infectious Diseases.

Carfì, A., Bernabei, R., & Landi, F. (2020). Persistent symptoms in patients after acute COVID-19. Jama, 324(6), 603–605. COVID, S. T. P. (2020). 19.(2020). Data Sebaran.

Cucunawangsih, C., Wijaya, R. S., Lugito, N. P. H., & Suriapranata, I. (2021). Post-vaccination cases of COVID-19 among healthcare workers at Siloam Teaching Hospital, Indonesia. International Journal of Infectious Diseases, 107, 268–270.

Flaxman, A., Marchevsky, N. G., Jenkin, D., Aboagye, J., Aley, P. K., Angus, B., Belij-Rammerstorfer, S., Bibi, S., Bittaye, M., & Cappuccini, F. (2021). Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002). The Lancet, 398(10304), 981–990.

Guo, Y.-R., Cao, Q.-D., Hong, Z.-S., Tan, Y.-Y., Chen, S.-D., Jin, H.-J., Tan, K.-S., Wang, D.-Y., & Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Military Medical Research, 7(1), 1–10.

Hu, L., Chen, S., Fu, Y., Gao, Z., Long, H., Ren, H., Zuo, Y., Wang, J., Li, H., & Xu, Q. (2020). Risk factors associated with clinical outcomes in 323 coronavirus disease 2019 (COVID-19) hospitalized patients in Wuhan, China. Clinical Infectious Diseases, 71(16), 2089–2098.

Kaur, S. P., & Gupta, V. (2020). COVID-19 Vaccine: A comprehensive status report. Virus Research, 198114.

Menni, C., Klaser, K., May, A., Polidori, L., Capdevila, J., Louca, P., Sudre, C. H., Nguyen, L. H., Drew, D. A., & Merino, J. (2021). Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. The Lancet Infectious Diseases.

Nabavi, N. (2020). Long covid: How to define it and how to manage it. British Medical Journal Publishing Group.

Petrilli, C. M., Jones, S. A., Yang, J., Rajagopalan, H., O’Donnell, L., Chernyak, Y., Tobin, K. A., Cerfolio, R. J., Francois, F., & Horwitz, L. I. (2020). Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. Bmj, 369.

Shoaib, N., Noureen, N., Munir, R., Shah, F. A., Ishtiaq, N., Jamil, N., Batool, R., Khalid, M., Khan, I., & Iqbal, N. (2021). COVID-19 severity: Studying the clinical and demographic risk factors for adverse outcomes. PloS One, 16(8), e0255999.

Sudre, C. H., Murray, B., Varsavsky, T., Graham, M. S., Penfold, R. S., Bowyer, R. C., Pujol, J. C., Klaser, K., Antonelli, M., & Canas, L. S. (2021). Attributes and predictors of long COVID. Nature Medicine, 27(4), 626–631.

Taquet, M., Dercon, Q., Luciano, S., Geddes, J. R., Husain, M., & Harrison, P. J. (2021). Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Medicine, 18(9), e1003773.

Wei, J., Stoesser, N., Matthews, P. C., Ayoubkhani, D., Studley, R., Bell, I., Bell, J. I., Newton, J. N., Farrar, J., & Diamond, I. (2021). Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom. Nature Microbiology, 6(9), 1140–1149.

Published
2022-12-12
Abstract viewed = 334 times