PENGGUNAAN CHLORHEXIDINE UNTUK PEMASANGAN DAN PERAWATAN KATETER URIN DALAM MENCEGAH CAUTI: A SCOPING REVIEW
Abstract
Prevention of catheter-associated urinary tract infections (CAUTI) can be done with simple initiatives such as catheter insertion and care can contribute to preventing infection, chlorhexidine is one of the commonly used antiseptic agents due to its cationic molecular nature with various antimicrobial activities, however, until now the choice of the concentration of the use of chlorhexidine is still a polemic in its use. Therefore, the aim of this review is to evaluate the use of chlorhexidine before urinary catheter insertion and treatment in preventing CAUTI. Manual reference searches were carried out using the scoping review method, through the PubMED, DOAJ, Science direct, EBSCO, ProQuest, Garuda, and Gray Literature databases (google scholar). The study was included based on PCC criteria (Population: patients with urinary catheters, Concept: Chlorhexidine use, Context: urinary catheter insertion and care), published from 2011-2021. A total of 171 studies were screened, the remaining eleven articles that met the inclusion criteria and were included in this review. Based on the results of the study found the use of Chlorhexidine with various concentrations, namely 0.05%, 0.1%, 0.5%, 0.9%, 2%, and 4% with various intervention uses, namely, SRV (sustained-release varnishes), periurethral cleaning before catheterization , cleaning urine bag, and bathing Chlorhexidine. The application of the use of chlorhexidine with a concentration of 0.5% - 4% is one of the strategies to prevent CAUTI at the time of insertion and treatment of urinary catheters, especially in the intensive care room.
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Andrade, V. L. F., & Fernandes, F. A. V. (2016). Prevention of catheter-associated urinary tract infection: implementation strategies of international guidelines. Revista Latino-Americana de Enfermagem, 24. https://doi.org/10.1590/1518-8345.0963.2678
Armiyati, Y., & Arifin, Z. (2013). Pembersihan urin bag dengan klorin terhadap jumlah kuman dalam urin pada pasien dengan kateter menetap di ruang B1 saraf RSUP Dr. Kariadi Semarang. Jurnal Keperawatan Medikal Bedah, 1(2), 97–104.
Bongkat, G., Bartoletti, R. R., Bruyere, F., Cai, T., Geerlings, S. E., Koves, B., … Wagenlehner, F. (2019). EAU Guidelines on urological infections. In European Association of Urology. Retrieved from http://www.uroweb.org/gls/pdf/15_Urological_Infections.pdf
Boyce, J. M., & Pittet, D. (2002). Guideline for hand hygiene in health-care settings: Recommendations of the healthcare infection control practices advisory committee and the HICPAC/SHEA/APIC/IDSA. Hand hygiene task force. In Infection Control and Hospital Epidemiology (Vol. 23). Retrieved from http://www.jstor.org/stable/10.1086/503164
Cao, Y., Gong, Z., Shan, J., & Gao, Y. (2018). Comparison of the preventive effect of urethral cleaning versus disinfection for catheter-associated urinary tract infections in adults: a network meta-analysis. International Journal of Infectious Diseases, 76, 102–108. https://doi.org/10.1016/j.ijid.2018.09.008
Chenoweth, C. E., & Saint, S. (2016). Urinary Tract Infections. Infectious Disease Clinics of North America, 30(4), 869–885. https://doi.org/10.1016/j.idc.2016.07.007
Duzkaya, D. S., Uysal, G., Bozkurt, G., Yakut, T., & Citak, A. (2017). Povidone-Iodine, 0.05% chlorhexidine gluconate, or water for periurethral cleaning before indwelling urinary catheterization in a pediatric intensive care: a randomized controlled trial. Journal of Wound, Ostomy and Continence Nursing, 44(1), 84–88. https://doi.org/10.1097/WON.0000000000000280
Ercole, F. F., Macieira, T. G. R., Wenceslau, L. C. C., Martins, A. R., Campos, C. C., & Chianca, T. C. M. (2013). Integrative review: Evidences on the practice of intermittent/indwelling urinary catheterization. Revista Latino-Americana de Enfermagem, 21(1), 459–468. https://doi.org/10.1590/S0104-11692013000100023
Fasugba, O., Cheng, A. C., Gregory, V., Graves, N., Koerner, J., Collignon, P., … Mitchell, B. G. (2019). Chlorhexidine for meatal cleaning in reducing catheter-associated urinary tract infections: a multicentre stepped-wedge randomised controlled trial. The Lancet Infectious Diseases, 19(6), 611–619. https://doi.org/10.1016/S1473-3099(18)30736-9
Flores-Mireles, A., Hreha, T. N., & Hunstad, D. A. (2019). Pathophysiology, treatment, and prevention of catheter-associated urinary tract infection. Topics in Spinal Cord Injury Rehabilitation, 25(3), 228–240. https://doi.org/10.1310/sci2503-228
Geerlings, S. E. (2016). Clinical presentations and epidemiology of urinary tract infections. In Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. https://doi.org/10.1128/9781555817404.ch2
Gefter, J. (Shenderovich), Zaks, B., Kirmayer, D., Lavy, E., Steinberg, D., & Friedman, M. (2018). Chlorhexidine sustained-release varnishes for catheter coating – dissolution kinetics and antibiofilm properties. European Journal of Pharmaceutical Sciences, 112(October 2017), 1–7. https://doi.org/10.1016/j.ejps.2017.10.041
Gould, C. V, Umscheid, C. A., Agarwal, R. K., Kuntz, G., Pegues, D. A., & the Healthcare Infection Control Practices Advisory Committee (HICPAC). (2019). Guideline for prevention of catheter- associated urinary tract infections 2009. In HICPAC : Healthcare Infection Control Practices Advisory Committee. Retrieved from https://www.cdc.gov/infectioncontrol/guidelines/cauti/
Hooton, T. M., Bradley, S. F., Cardenas, D. D., Colgan, R., Geerlings, S. E., Rice, J. C., … Nicolle, L. E. (2010). Diagnosis, prevention, and treatment of catheter-aassociated urinary tract infection in adults: 2009 international clinical practice guidelines from the infectious diseases society of America. Clinical Infectious Diseases, 50(5), 625–663. https://doi.org/10.1086/650482
Huang, H. P., Chen, B., Wang, H. Y., & He, M. (2016). The efficacy of daily chlorhexidine bathing for preventing healthcare-associated infections in adult intensive care units. Korean Journal of Internal Medicine, 31(6), 1159–1170. https://doi.org/10.3904/kjim.2015.240
Huang, K., Liang, J., Mo, T., Zhou, Y., & Ying, Y. (2018). Does periurethral cleaning with water prior to indwelling urinary catheterization increase the risk of urinary tract infections? a systematic review and meta-analysis. American Journal of Infection Control, 46(12), 1400–1405. https://doi.org/10.1016/j.ajic.2018.02.031
Huang, S. S., Septimus, E., Hayden, M. K., Kleinman, K., Sturtevant, J., Avery, T. R., … Weinstein, R. A. (2016). Effect of body surface decolonisation on bacteriuria and candiduria in intensive care units: an analysis of a cluster-randomised trial. The Lancet Infectious Diseases, 16(1), 70–79. https://doi.org/10.1016/S1473-3099(15)00238-8
JBI. (2021). JBI Manual for Evidence Synthesis. In JBI Manual for Evidence Synthesis. https://doi.org/10.46658/jbimes-20-01
Jeong, I., Park, S., Jeong, J. S., Kim, D. S., Choi, Y. S., Lee, Y. S., & Park, Y. M. (2010). Comparison of catheter-associated urinary tract infection rates by perineal care agents in intensive care units. Asian Nursing Research, 4(3), 142–150. https://doi.org/10.1016/S1976-1317(10)60014-X
Karpinski, T. M., & Szkaradkiewicz, A. K. (2015). Chlorhexidine - Pharmaco-biological activity and application. European Review for Medical and Pharmacological Sciences, 19(7), 1321–1326.
Kitagawa, K., Shigemura, K., Yamamichi, F., Alimsardjono, L., Rahardjo, D., Kuntaman, K., … Fujisawa, M. (2018). International comparison of causative bacteria and antimicrobial susceptibilities of urinary tract infections between Kobe, Japan, and Surabaya, Indonesia. Japanese Journal of Infectious Diseases, 71(1), 8–13. https://doi.org/10.7883/yoken.JJID.2017.233
Letica-Kriegel, A. S., Salmasian, H., Vawdrey, D. K., Youngerman, B. E., Green, R. A., Furuya, E. Y., … Perotte, R. (2019). Identifying the risk factors for catheter-associated urinary tract infections: a large cross-sectional study of six hospitals. BMJ Open, 9(2), 1–7. https://doi.org/10.1136/bmjopen-2018-022137
Letzelter, J., Hill, J. B., & Hacquebord, J. (2019). An overview of skin antiseptics used in orthopaedic surgery procedures. Journal of the American Academy of Orthopaedic Surgeons, 27(16), 599–606. https://doi.org/10.5435/JAAOS-D-18-00105
Meddings, J., Rogers, M. A. M., Krein, S. L., Fakih, M. G., Olmsted, R. N., & Saint, S. (2014). Reducing unnecessary urinary Catheter use and other strategies to prevent catheter-associated urinary tract infection: An integrative review. BMJ Quality and Safety, 23(4), 277–289. https://doi.org/10.1136/bmjqs-2012-001774
Mitchell, B., Curryer, C., Holliday, E., Rickard, C. M., & Fasugba, O. (2021). Effectiveness of meatal cleaning in the prevention of catheter-associated urinary tract infections and bacteriuria: An updated systematic review and meta-analysis. BMJ Open, 11(6), 1–11. https://doi.org/10.1136/bmjopen-2020-046817
Nadimpalli, G., O’Hara, L. M., Leekha, S., Calfee, D. P., Miller, L. G., Pineles, L., … Harris, A. D. (2019). Association between chlorhexidine gluconate concentrations and resistant bacterial bioburden on skin. Infect Control Hosp Epidemiol, 40(12), 1430–1432. https://doi.org/10.1017/ice.2019.265
Nicolle, L. E. (2015). Infections associated with urinary catheters. Clinical Infectious Disease, Second Edition, (1), 722–727. https://doi.org/10.1017/CBO9781139855952.122
Noto, M. J., Domenico, H. J., Byrne, D. W., Talbot, T., Rice, T. W., Bernard, G. R., & Wheeler, A. P. (2015). Chlorhexidine Bathing and Healthcare-Associated Infections: A Randomized Clinical Trial. JAMA - Journal of the American Medical Association, 313(4), 369–378. https://doi.org/10.1001/jama.2014.18400
Pallotto, C., Fiorio, M., De Angelis, V., Ripoli, A., Franciosini, E., Quondam Girolamo, L., … Baldelli, F. (2019). Daily bathing with 4% chlorhexidine gluconate in intensive care settings: a randomized controlled trial. Clinical Microbiology and Infection, 25(6), 705–710. https://doi.org/10.1016/j.cmi.2018.09.012
Popp, J. A., Layon, A. J., Nappo, R., Richards, W. T., & Mozingo, D. W. (2014). Hospital-acquired infections and thermally injured patients: Chlorhexidine gluconate baths work. American Journal of Infection Control, 42(2), 129–132. https://doi.org/10.1016/j.ajic.2013.08.015
Sarani, H., Pishkar Mofrad, Z., Faghihi, H., & Ghabimi, M. (2020). Comparison of the Effect of Perineal Care with Normal Saline and 2% Chlorhexidine Solution on the Rate of Catheter-Associated Urinary Tract Infection in Women Hospitalized in Intensive Care Units: A Quasi-Experimental Study. Medical - Surgical Nursing Journal, 9(2). https://doi.org/10.5812/msnj.106739
Schmudde, Y., Olson-Sitki, K., Bond, J., & Chamberlain, J. (2019). Navel to knees with chlorhexidine gluconate preventing catheter-associated urinary tract infections. Dimensions of Critical Care Nursing, 38(5), 236–240. https://doi.org/10.1097/DCC.0000000000000371
Schwenger, E. M., Tejani, A. M., & Loewen, P. S. (2015). Probiotics for preventing urinary tract infections in adults and children. Cochrane Database of Systematic Reviews, 2015(12). https://doi.org/10.1002/14651858.CD008772.pub2
Shaheen, G., Akram, M., Jabeen, F., Ali Shah, S. M., Munir, N., Daniyal, M., … Khan, M. (2019). Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review. Clinical and Experimental Pharmacology and Physiology, 46(7), 613–624. https://doi.org/10.1111/1440-1681.13092
Shapur, N. K., Duvdevani, M., Friedman, M., Zaks, B., Gati, I., Lavy, E., … Steinberg, D. (2012). Sustained release varnish containing chlorhexidine for prevention of biofilm formation on urinary catheter surface: In vitro study. Journal of Endourology, 26(1), 26–31. https://doi.org/10.1089/end.2011.0140
Shuman, E. K., & Chenoweth, C. E. (2018). Urinary catheter-associated infections. Infectious Disease Clinics of North America, 32(4), 885–897. https://doi.org/10.1016/j.idc.2018.07.002
Swan, J. T., Ashton, C. M., Bui, L. N., Pham, V. P., Shirkey, B. A., Blackshear, J. E., … Wray, N. P. (2016). Effect of Chlorhexidine Bathing Every Other Day on Prevention of Hospital-Acquired Infections in the Surgical ICU: A Single-Center, Randomized Controlled Trial. Critical Care Medicine, 44(10), 1822–1832. https://doi.org/10.1097/CCM.0000000000001820
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., … Straus, S. E. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Wei, L., Li, Y., Li, X., Bian, L., Wen, Z., & Li, M. (2019). Chlorhexidine-impregnated dressing for the prophylaxis of central venous catheter-related complications: a systematic review and meta-Analysis. BMC Infectious Diseases, 19(1), 1–12. https://doi.org/10.1186/s12879-019-4029-9
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