STUDI PENGGUNAAN DEKSAMETASON PADA PASIEN COVID-19 DERAJAT BERAT DENGAN KOMORBID DIABETES MELLITUS
Abstrak
Pemberian deksametason pada pasien dengan penyakit diabetes perlu mendapat perhatian karena kortikosteroid dapat meningkatkan konsentrasi glukosa darah. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan Deksametason pada pasien COVID-19 derajat berat dan bagaimana regulasi glukosa darah pasien COVID-19 derajat berat pada pasien dengan komorbid Diabetes Mellitus. Kriteria inklusi pasien COVID-19 derajat berat dengan komorbid Diabetes Mellitus yang menggunakan obat Deksametason dan kelompok terapi serta menerima terapi Insulin dengan atau tanpa OAD di instalasi rawat inap. Data sampel yang diperoleh dari rekam medik pasien yaitu sebanyak 27 pasien yang memenuhi kriteria inklusi dan eksklusi terdiri dari 70% berjenis kelamin laki-laki dan 30% berjenis kelamin perempuan. Deksametason dosis 1 x 6 mg iv paling banyak menggunakan kombinasi terapi A lama pemberian 8 hari dan memiliki rata-rata lama rawat inap yaitu 13 hari. Rata rata lama rawat inap paling singkat yaitu 12 hari pada pasien yang menerima deksametason dengan terapi C lama pemberian 10 hari sementara terapi B lama pemberian 5 hari memperoleh rata-rata rawat inap 14 hari. Pemberian Deksametason dosis 1 x 6mg iv efektif pada pasien COVID-19 derajat berat dengan komorbid Diabetes Mellitus berdasarkan lama rawat inap berturut-turut 13 hari, 14 hari, dan 12 hari dengan perbaikan kondisi klinis saturasi oksigen sebesar 91%, 100%, 100%; RT-PCR/Rapid Ag menjadi negatif 74%, 100%, 100%; perbaikan hasil foto toraks yaitu 83%, 33%, 100%. Efek glukokortikoid deksametason pada pasien komorbid Diabetes Mellitus diregulasi dengan pemberian insulin long acting, insulin rapid acting dan oral anti diabetes.
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