PEMANFAATAN DANDELION (TARAXACUM OFFICINALE) PADA DIABETES MELLITUS TIPE 2
Abstract
Diabetes mellitus was one of WHO priority diseases because the number of sufferers is quite high and always increased in every country, especially in Indonesia. Efforts to manage diabetes mellitus from non-pharmacological, pharmacological, to traditional treatments have been carried out. Indonesia is also a country that has a variety of nutritious plants, but only a few plants have been used as traditional medicine. The purpose of this study was to find out how the utilization would be done using dandelion or Taraxacum officinale for type 2 diabetes mellitus so that the results would be useful to increase knowledge for health providers and the people of Indonesia in utilizing the natural resources in Indonesia. This type of research was a literature review and the method used in this study literature was collecting 21 literature from books and 30 case report and research article journals. Conclusion: One of the medicinal plants found in Indonesia was dandelion plant (Taraxacum officinale) which was known to have antihyperglycemic or antidiabetic effects, but its use in Indonesia was quite rare. Antidiabetic mechanisms of this plant are reabsorption of the glucose in the kidneys, reducing the activity of the enzyme alpha-amylase and alpha-glucosidase, reducing glucose levels in the blood, and inhibiting the flow of potassium channels.
ABSTRAK
Diabetes mellitus merupakan penyakit yang menjadi salah satu pusat perhatian WHO karena jumlah penderitanya yang cukup tinggi dan selalu mengalami peningkatan pada setiap negara, khususnya di Indonesia. Upaya penatalaksanaan diabetes mellitus dari tatalaksana non-farmakologi, farmakologi, hingga pengobatan tradisional sudah banyak dilakukan. Indonesia juga merupakan negara yang memiliki beragam tanaman berkhasiat, tetapi hanya sedikit tanaman yang sudah digunakan sebagai tanaman sebagai obat tradisional. Tujuan penelitian ini adalah untuk mengetahui bagaimana pemanfaatan yang dapat dilakukan menggunakan dandelion atau taraxacum officinale terhadap kondisi diabetes mellitus tipe 2. Sehingga hasilnya dapat bermanfaat untuk menambah pengetahuan bagi penatalaksana kesehatan dan masyarakat Indonesia dalam memanfaatkan kekayaan sumber daya alam di Indonesia dengan baik. Jenis penelitian ini adalah tinjauan literatur dengan metode yang digunakan adalah mengumpulkan hasil baca dari sumber berupa 21 buku dan 30 jurnal laporan kasus dan jurnal artikel penelitian. Kesimpulan: Salah satu tanaman obat yang terdapat di Indonesia adalah tanaman dandelion (Taraxacum officinale) yang diketahui memiliki efek antihiperglikemia atau antidiabetes, tetapi penggunaannya di Indonesia masih jarang. Mekanisme antidiabetes yang terjadi adalah mereabsorpsi glukosa di ginjal, mengurangi aktivitas enzim alfa-amylase dan alfa-glukosidase, mengurangi kadar glukosa dalam darah, serta menghambat aliran saluran kalium.
Downloads
References
Ministry of Public Health and Sanitation. National Clinical Guidelines For Management of Diabetes Mellitus. Nairobi; 2010.
Joshi SR, Parikh RM, Das AK. Insulin--history, biochemistry, physiology and pharmacology. J Assoc Physicians India. 2007;55 Suppl(December 1921):19-25.
International Diabetes Federation. Global Diabetes Plan 2011-. New York; 2011.
WHO. Global Report on Diabetes. Geneva; 2016.
Forouhi NG, Wareham NJ. Epidemiology of diabetes. Med (United Kingdom). 2014;47(1):22-27.
Wild S, Roglic G, Green A, Sicree R KH. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053.
Whiting DR, Guariguata L, Weil C, Shaw J. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94(3):311-321.
Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-281. doi:10.1016/j.diabres.2018.02.023
Buowari OY. Diabetes Mellitus in Developing Countries and Case Series. Diabetes Mellit - Insights Perspect. 2013.
Rhee E. Review Article Diabetes in Asians. Endocrinol ogy Metab. 2015;30:263-269.
Soewondo P, Ferrario A, Tahapary DL. Challenges in diabetes management in Indonesia: A literature review. Global Health. 2013;9(1):1-17. doi:10.1186/1744-8603-9-63
Kementerian Kesehatan RI. Info Datin: Situasi Dan Analisis Diabetes.; 2014.
Kementerian Kesehatan RI. Tahun 2030 Prevalensi Diabetes Melitus Di Indonesia Mencapai 21,3 Juta Orang. Kementrian Kesehatan RI.
Kementerian Kesehatan RI. Pharmaceutical Care Untuk Penyakit Diabetes Mellitus. Jakarta: Kementerian Kesehatan RI; 2005.
Simó R, Hernández C. Treatment of diabetes mellitus: General goals, and clinical practice management. Rev Esp Cardiol. 2002;55(8):845-860. doi:10.1016/S0300-8932(02)76714-6
Paswan SK, Verma P, Raj A, Azmi L, Shrivastava S, Rao C V. The Role of Nutrition Therapy in the Management of Diabetes Mellitus. Nutr Clin Care. 2016;3(1):1-6.
Evert AB, Boucher JL, Cypress M, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care. 2014;37(1):120-143.
Sami W, Butt TA, Shafique N, Hamid MRA. Effect of diet on type 2 diabetes mellitus: A review. 2017;11(2).
Colberg SR, Sigal RJ, Fernhall B, et al. Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: Joint position statement. Diabetes Care. 2010;33(12). doi:10.2337/dc10-9990
Colberg SR, Sigal RJ, Yardley JE, et al. Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065-2079. doi:10.2337/dc16-1728
Gautier J, Duclos M, Oppert JM, et al. Physical activity and type 2 diabetes. Recommandations of the SFD (Francophone Diabetes Society) diabetes and physical activity working group. Diabetes Metab J. 2015;39(October):205-216. doi:10.1016/j.diabet.2013.03.005
American Diabetes Associaion. Pharmacologic approaches to glycemie treatment: Standards of medical care in diabetes-2019. Diabetes Care. 2019;42(1):90-102. doi:10.6314/JIMT.201804_29(2).06
Wall RT. Endocrine disease. In: Stoelting’s Anesthesia and Co-Existing Disease. Philadelphia: Elsevier; 2018. doi:10.1016/B978-0-323-40137-1.00023-5
Skugor M. Diabetes Mellitus. In: Ryan’s Retina. Philadelphia: Elsevier Inc.; 2019:1055-1060.
Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012;22(11):820-827.
Bajaj S. RSSDI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2017. Vol 38.; 2018.
Kooti W, Farokhipour M, Asadzadeh Z, Ashtary-Larky D, Asadi-Samani M. The role of medicinal plants in the treatment of diabetes: a systematic review. Electron physician. 2016;8(1):1832-1842. doi:10.19082/1832
Mitra R, Mitchell, Gray C, Orbell J, Coulepis T, Muralitharan MS. Medicinal Plants of Indonesia. APBN. 2007;11(11):726-743.
Departemen Perdagangan RI. Indonesian Herbal The Traditional Therapy. Jakarta: Ministry Trade Research & Development Agency; 2009.
Indonesian Traditional Medicine Nationat Strategy and Scope Cooperation. Traditional Medicine in Republic of Indonesian. Jakarta: Indonesian Traditional Medicine Nationat Strategy and Scope Cooperation; 2007.
Kementerian Pertanian RI. Statistik Produksi Hortikultura Tahun 2014. Jakarta: Kementerian Pertanian RI; 2014.
Kementerian Perdagangan RI. Info Komoditi Tanaman Obat. Jakarta: Kementerian Perdagangan RI; 2017.
Yarnell E, Abascal K. Dandelion (Taraxacum officinale and T mongolicum). Integr Med. 2009;8(2):35.
Fatima T, Bashir O, Naseer B, Hussain SZ. Dandelion: Phytochemistry and clinical potential. J Med Plants Stud. 2018;6(2):198-202.
WHO. Definition, Diagnosis and Classification Pf Diabetes Mellitus and Its Complications. Geneva: WHO; 1999.
American Diabetes Association. Diagnosis and classification of autoimmune diabetes mellitus. Diabetes Care. 2010;33(1).
Reinehr T. Type 2 diabetes mellitus in children and adolescents. World J Diabetes. 2013;4(6).
American Diabetes Association. Standards of Medical Care in Diabetes-2018. Vol 41. USA: American Diabetes Association; 2018.
Olokoba AB, Obateru OA, Olokoba LB. Type 2 Diabetes Mellitus: A Review of Current Trends. Oman Med J. 2012;2(4).
McCall, Saunders, Gosmanov, Gosmanova. Diabetes mellitus in adults. In: Conn’s Current Therapy. Philadelphia: Elsevier; 2019.
Baynest HW. Classification, Pathophysiology, Diagnosis and Management of Diabetes Mellitus. J Diabetes Metab. 2015;6(5).
Kahn SE, Cooper ME, Del Prato S. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future. Lancet. 2014;383(9922):1068-1083.
Kaku K. Pathophysiology of Type 2 Diabetes and Its Treatment Policy. JMAJ. 2010;53(1):41-46.
Stewart-Wade SM, Neumann S, Collins LL, Boland GJ. The biology of Canadian weeds. 117. Taraxacum officinale G. H. Weber ex Wiggers. Can J Plant Sci. 2002.
Badrunasar A, Santoso HB. Tumbuhan Liar Berkhasiat Obat. Bogor: Forda Press; 2017.
Dalimarta S. Ensiklopedi Tanaman Obat Indonesia. Jakarta: Dinamika Media; 2008.
Wirngo FE, Lambert MN, Jeppesen PB. The physiological effects of dandelion (Taraxacum officinale) in type 2 diabetes. Rev Diabet Stud. 2016;13(2-3):113-131.
Sekhon-Loodu S, Rupasinghe HPV. Evaluation of Antioxidant, Antidiabetic and Antiobesity Potential of Selected Traditional Medicinal Plants. Front Nutr. 2019;6(April):1-11.
Lee YW, Choi SY, Lee EK, Sohn JH, Park J-W, Hong C-S. Cross-allergenicity of pollens from the Compositae family: Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale. Ann Allergy, Asthma Immunol. 2007;99(6):526-533. doi:10.1016/s1081-1206(10)60382-1
Zhu M, Wong PY, Li RC. Effects of Taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci. 1999;88(6):632-634. doi:10.1021/js980367q
Copyright (c) 2019 Jurnal Kesehatan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
