Herbs Used as Antidiabetic : A Review

Jufri Ubrusun; Suharjono Suharjono; Irma Novrianti

doi:10.24252/djps.v4i2.23461

Jufri Ubrusun Universitas Airlangga Surabaya
(ID)
Suharjono Suharjono Universitas Airlangga Surabaya
(ID)
Irma Novrianti Universitas Airlangga Surabaya
(ID)

DOI: https://doi.org/10.24252/djps.v4i2.23461

Abstract

Diabetes mellitus is a syndrome characterized by a condition of hyperglycemia, and changes in the metabolism of lipids, carbohydrates, and proteins. Diabetes mellitus is characterized by an increase in glucose levels caused by insulin deficiency either in absolute or relative terms. Diabetes mellitus therapy is a long-term therapy and is relatively expensive. Therefore, it is necessary to look for effective alternative drugs with low prices such as herbal medicines derived from plants. Indonesia is one of the countries that has a diversity of plants, so many plants that grow in Indonesia can be used as an alternative therapy to overcome diabetes mellitus. This paper aims to provide a relevant review of medicinal plants used for diabetes mellitus that has been carried out in research on tested animals. This research was conducted by searching for national and international articles from the internet, which were searched from 2011 to 2019, including original articles, and experimental articles, about Traditional medicine for diabetics. The following keywords are used : [[ “studi in vivo tumbuhan obat untuk diabetes” OR “Uji efektifitas ekstrak tumbuhan sebagai antidiabetik” OR “tumbuhan sebagai antidiabetik” ]] OR [["Test extract activity against diabetic mice" OR "antidiabetic plant" OR "antidiabetic herbal medicine" OR "antidiabetic in rat”, “Traditional medicine of diabetisin Indonesia” ]]. From the results of the literature study, it was found that 21 articles with 24 medicinal plants were tested in vivo on test animals to reduce blood sugar in diabetes mellitus. These medicinal plants contain compounds of the type of flavonoids, alkaloids, tannins, saponins, polyphenols, terpenoids, and phenolics that can have a therapeutic effect on decreasing blood sugar levels in test animals.

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Author Biography

Jufri Ubrusun, Universitas Airlangga Surabaya

Departemen of Diploma-III Pharmacy

References

Aisha, A. F., Ismail, Z., Abu-Salah, K. M., Siddiqui, J. M., Ghafar, G., & Abdul Majid, A. M. S. (2013). Syzygium campanulatum korth methanolic extract inhibits angiogenesis and tumor growth in nude mice. BMC Complementary and Alternative Medicine, 13(1), 168. https://doi.org/10.1186/1472-6882-13-168

Afolayan, A. & Sunmonu, T. (2010). In vivo Studies on Antidiabetic Plants Used in South African Herbal Medicine. J. Clin. Biochem. Nutr, 47(2), 98-106. https://doi.org/10.3164/jcbn.09-126R

Akash, M. S. H., Rehman, K., & Chen, S. (2013). Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. Journal of Cellular Biochemistry, 114(3), 525–531. https://doi.org/10.1002/jcb.24402

Anas, Y., Fithria, R. F., Nuria, M. C., Martha, A., Nugroho, A. E., & Astuti, P. (2015). Aktivitas Antidiabetes Fraksi n-Heksana Ekstrak Etanol Daun Lenglengan (Leucas lavandulifolia JE. Smith) Pada Tikus DM Tipe-2 Yang Mengalami Resistensi Insulin. Kartika Jurnal Ilmiah Farmasi, 3(1), 33. https://doi.org/10.26874/kjif.v3i1.33

Arokiyaraj, S., R. Balamurugan., and P. Augustian. (2011). Antihiperglycemi Effect Of Hypericum Perforatum Ethyl Acetate Extract On Streptozotocin Induced Diabetic Rats. Asian pacific journal of tropical biomedicine. 1(5), 386–390. https://dx.doi.org/10.1016/S2221-1691(11)60085-3

Balogun, F. O., Tshabalala, N. T., & Ashafa, A. O. T. (2016). Antidiabetic Medicinal Plants Used by the Basotho Tribe of Eastern Free State: A Review. Journal of Diabetes Research, 2016, 1–13. https://doi.org/10.1155/2016/4602820

Baroroh, F., Aznam, N., & Susanti, H. (2011). Uji Efek Antihiperglikemik Ekstrak Etanol Daun Kacapiring (Gardenia augusta, Merr) Pada Tikus Putih Jantan Galur Wistar. Jurnal Ilmiah Kefarmasian. 1(1), 43-53. http://dx.doi.org/10.12928/pharmaciana.v1i1.515

Bindu, J. & Narendhirakannan R.T. (2019). Role of medicinal plants in the management of diabetes mellitus: A review. 3 Biotech, 9(1), 4. https://doi.org/10.1007/s13205-018-1528-0

Bisala, F. K., & Ya’la, U. F. (2019). Uji Efek Antidiabetes Ekstrak Etanol Daun Talas Pada Tikus Putih Jantan Hiperkolesterolemia-Diabetes. Farmakologika Jurnal Farmasi. 16(1). 13-24

Cahyanto, H. A., & Supriyatna. N. (2013). Antidiabetic Activity of Tabat Barito Leaf Extract (Ficus deltoidea, Jack) in Wistar Rats. Biopropal Industri. 4(1). 17-21.

Dewanti, N. I., & Sofian, F. F. (2019). Pharmacological Activity of Pandan Leaf Extract (Pandanus amaryllifolius Roxb.). Farmaka Suplemen. 15(2). 186-194. https://doi.org/10.24198/jf.v15i2.13239

Dinesh, K.B., Mitra, A. & Manjunatha, M., (2009). In Vitro and In Vivo Studies Of Antidiabetic Indian Medical Plants ; A Review . Journal of Herbal Medicine and Toxicology, 3(2). 9-14

Fiana, N., & Oktaria, D (2016). Pengaruh Kandungan Saponin dalam Daging Buah Mahkota Dewa (Phaleria macrocarpa) terhadap Penurunan Kadar Glukosa Darah. Majority. 5(4). 128-132

Fitriani, N., Layal, K., & Kamila, K. (2017). Aktivitas Antidiabetes Kombinasi Ekstrak Etanol Daun Andrographis Paniculata dan Vernonia Amygdalina. Syifa’ MEDIKA: Jurnal Kedokteran dan Kesehatan, 7(2), 104. https://doi.org/10.32502/sm.v7i2.1371

Fitriani, N., & Erlyn, P. (2019). Aktivitas Antidiabetik Kombinasi Ekstrak Etanol Daun Ciplukan (Physalis angulata) dan Daun Gaharu (Aquilaria malaccensis) pada Tikus Diabetes. Syifa’ MEDIKA: Jurnal Kedokteran dan Kesehatan, 9(2), 70. https://doi.org/10.32502/sm.v9i2.1660

Gushiken, L. F., Beserra, F. P., Rozza, A. L., Bérgamo, P. L., Bérgamo, D. A., & Pellizzon, C. H. (2016). Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects. The Review of Diabetic Studies, 13(2–3), 96–112. https://doi.org/10.1900/RDS.2016.13.96

Isdamayani, L., & Panunggal, B. (2015). Kandungan Flavonoid, Total Fenol, Dan Antioksidan Snack Bar Sorgum Sebagai Alternatif Makanan Selingan Penderita Diabetes Mellitus Tipe 2. Journal of Nutrition College, 4(4), 342–349. https://doi.org/10.14710/jnc.v4i4.10108

Kaempe, H. S., Suryanto, E., & Kawengian, S. E. S. (2013). Potensi Ekstrak Fenolik Buah Pisang Goroho (Musa spp.) Terhadap Gula Darah Tikus Putih (Rattus Norvegicus). Chemitry Progress, 6(1). 6-9. https://doi.org/10.35799/cp.6.1.2013.2064

Gushiken, L. F., Beserra, F. P., Rozza, A. L., Bérgamo, P. L., Bérgamo, D. A., & Pellizzon, C. H. (2016). Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects. The Review of Diabetic Studies, 13(2–3), 96–112. https://doi.org/10.1900/RDS.2016.13.96

Lahamado, O. T., Sabang, S. M., & Mustapa, K. (2017). Tamarind (Tamarindus indica L.) Leaves Extracts as Antidiabetic. Jurnal Akademika Kimia, 6(1), 1. https://doi.org/10.22487/j24775185.2017.v6.i1.9221

Lukiati, B., Maslikah, S. I., & N, N. (2016). The Potenty of Sechium edule Ethanolic Extract to Repair Beta Pancreas Cells and Nitrogen Oxide Concentration in Streptozotocin-induced Diabetic Rat. Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences, 10(1). https://doi.org/10.21157/j.ked.hewan.v10i1.3365

Makhija, I. K., Chandrashe, K. S., Richard, L., & Jaykumar, B. (2011). Phytochemical and Pharmacological Profile of Leucas lavandulaefolia: A review. Research Journal of Medicinal Plant, 5(5), 500–507. https://doi.org/10.3923/rjmp.2011.500.507

Miten L, S., Setiasih, N., & Widyastuti, S. (2014). The Effect Of Stem Bark Extract Of Moringa Lowering The Level Of Blood Glucose In Hperglicemic Rat Indonesia Medicus Veterinus. 3(4). 292-299

Monday, O. M., & Uzoma, A. I. (2013). Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 3(8), 628–633. https://doi.org/10.1016/S2221-1691(13)60127-6

Monisa, F. S., Maria, B., & Mega, S,. (2016). Tannin Extract Potential of Surian Leaf and Bark as α-Glucosidase Inhibitor. Journal of Tropical Woods Sciences and Tecnology, 14(2), 156-164. https://doi.org/10.51850/jitkt.v14i2.331

Mohammed, A., Ibrahim, M., & Islam, M. (2014). African Medicinal Plants with Antidiabetic Potentials: A Review. Planta Medica, 80(5), 354–377. https://doi.org/10.1055/s-0033-1360335

Noer, S., Pratiwi, R. D., & Gresinta, E. (2018). Penetapan Kadar Senyawa Fitokimia (Tanin, Saponin dan Flavonoid) sebagai Kuersetin Pada Ekstrak Daun Inggu (Ruta angustifolia L.). Jurnal Eksakta, 18(1), 19–29. https://doi.org/10.20885/eksakta.vol18.iss1.art3

Nurdin, H., Ekaprasada, M. T., & Suciati, D. (2016). Isolation and Characterization Flavonoid From the Bark of Toona Surian (Blume) Merr. Journal of Chemical and Pharmaceutical Research,. 8(6). 156-159.

Prameswari, O. M., & Widjanarko, S. B. (2014) The Effect of Water Extract of Pandan Wangi Leaf to Decrease Blood Glucose Levels and Pancreas Histopathology at Diabetes Mellitus Rats. Jurnal Pangan dan Agroindustri, 2(2). 16-27.

Radiansah, R. (2013). Moringa Leaves Extract (Moringa Oleivera) as An Alternative to Reduce Blood Sugar Levels on Mice. Jurnal Akademika Kimia, 2(2), 54-61.

Sangeetha, K. S. S., Umamaheswari, S., Reddy, C. U. M., & Kalkura, S. N. (2016). Flavonoids : Therapeutic Potential of Natural Pharmacological Agents. International Journal of Pharmaceutical Sciences and Research, 7(10). 3924-3930.

Sasmita, F. W., Susetyarini, E., Husamah, H., & Pantiwati, Y. (2017). Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan. Biosfera, 34(1), 22. https://doi.org/10.20884/1.mib.2017.34.1.412

Sitorus, R. M. H., Wullur, A. C., & Yamlean, P. V. Y. (2012). Isolasi dan Identifikasi Senyawa Flavonoid Pada Daun Adam Hawa (Rhoeo discolor). Pharmacon, 1(1). 53-57. https://doi.org/10.35799/pha.1.2012.446

Sundhani, E., Syarifah, D. C. N., Zumrohani, L. R., Nurulita, N. A., & Dukuhwaluh, J. R. (2016). The Effect Of Adam Hawa (Rhoeo Discolor) And Pucuk Merah (Syzygium Campanulatum Korth.) Leaves Ethanolic Extract To Decrease Blood Glucose Level On Rats Male Strain Wistar Induced With Glucose. Pharmacy, 13(2). 137-149.

Syafnir, L., & Krishnamurti, Y. (2014). Uji Aktivitas Antidiabetes Ekstrak Etanol Kulit Jengkol (Archidendron pauciflorum (BENTH.). Prosiding SNaPP2014 Sains, Teknologi, dan Kesehatan, 4(1). 65-72.

Theresia, R., Falah, S., & Safithri, M. (2017). Aktivitas antihiperglikemia ekstrak kulit dan daun surian (Toona sinensis) pada tikus diabetes (Sprague-dawley) yang diinduksi streptozotocin. Jurnal Gizi dan Pangan, 12(3), 187–199. https://doi.org/10.25182/jgp.2017.12.3.187-199

Wahyuni, Sri. (2017). Ekstrak Daun Meniran (Phyllanthus niruri L.) Memperbaiki Kerusakan Sel-ᵦ pankreas dan Menurunkan Kadar Gula Darah Tikus Wistar Hiperglikemia Diinduksi Aloksan. Intisari Sains Medis, 8(2). 160-163.

Wehantouw, F., & Manurung, S. (2011). Antihyperglicemic activity of mangosteen pericarp extract (Garcinia Mangosteen L.) on Rats induced with sucrose. Chemistry Progress. 4(2). 89-96. https://doi.org/10.35799/cp.4.2.2011.4980

Yuda, I Ketut Angga et al. 2013. Identification Of Ethanol Extract Pare Fruit And Its Reduction Effect Of White Male Rats Glucose Level With Aloksan Induction. Buletin Veteriner Udayana, 5(2). 87-95.