Successful Multidrug Chemotherapy for Rhabdomyosarcoma in a Seven-Year-Old Girl: A Case Report
Abstract
The most frequent soft tissue cancer in children is rhabdomyosarcoma (RMS). A diagnosis typically occurs between the ages of 5 and 6 in women. We report a seven-year-old girl was referred to Hospitals with complaints of a protruding left eye. The swelling was presented in July 2021, which was small earlier but has increased and become more prominent. An examination of the left eyelid showed a 2.5 x 2.5 x 1.5 cm solid mass with edema, erythema, and secretion in the superior and inferior affected eyelid. A Head CT scan revealed a left superolateral lacrimal duct tumour with a normal intracerebral structure. The histopathology examination found dacryoadenitis with an RMS tumour. This patient was treated using the RMS multidrug chemotherapy protocol (vincristine, actinomycin, and cyclophosphamide) for three sessions, which decreased tumour progressivity five months later. Early and appropriate treatment of this patient with chemotherapy regimens according to the protocol for RMS has a good prognosis.
References
Ratnaningsih T, Hurimah W. Rhabdomyosarcoma metastases to the bone marrow of a 2-year-old male patient: A case report. JKKI J Kedokt Dan Kesehat Indones. Published online August 31, 2020:198-203. doi:10.20885/JKKI.Vol11.Iss2.art13
Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tsuchiya H. Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma. Cancers. 2020;12(7):1758. doi:10.3390/cancers12071758
Albalawi ED, Alkatan HM, Elkhamary SM, Safieh LA, Maktabi AMY. Genetic profiling of rhabdomyosarcoma with clinicopathological and radiological correlation. Can J Ophthalmol. 2019;54(2):247-257. doi:10.1016/j.jcjo.2018.03.011
Jurdy L, Merks JHM, Pieters BR, et al. Orbital rhabdomyosarcomas: A review. Saudi J Ophthalmol. 2013;27(3):167-175. doi:10.1016/j.sjopt.2013.06.004
Bravo-Ljubetic L, Peralta-Calvo J, Larrañaga-Fragoso P, Pascual NO, Pastora-Salvador N, Gomez JA. Clinical Management of Orbital Rhabdomyosarcoma in a Referral Center in Spain. J Pediatr Ophthalmol Strabismus. 2016;53(2):119-126. doi:10.3928/01913913-20160122-02
Kaseb H, Kuhn J, Babiker HM. Rhabdomyosarcoma. In: StatPearls. StatPearls Publishing; 2022. Accessed December 17, 2022. http://www.ncbi.nlm.nih.gov/books/NBK507721/
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S. Orbital Rhabdomyosarcoma. Cancer Control. 2004;11(5):328-333. doi:10.1177/107327480401100507
Nicula C, Nicula D, Blidaru M, Ghiţuică A, Neamtu S, Saplonţai-Pop A. Orbital Rhabdomyosarcoma with a good life prognosis after surgical treatment in a 14-year-old patient. Open Med. 2014;9(3):394-399. doi:10.2478/s11536-013-0289-8
Terezakis SA, Wharam MD. Radiotherapy for Rhabdomyosarcoma: Indications and Outcome. Clin Oncol. 2013;25(1):27-35. doi:10.1016/j.clon.2012.07.009
Ning Z, Liu X, Qin G, Wei L, Li X, Shen J. Evaluation of clinical efficacy of Chemotherapy for Rhabdomyosarcoma in children. Pak J Med Sci. 2020;36(5). doi:10.12669/pjms.36.5.1829
Thien HH, Kim Hoa NT, Duy PC, Carlos RG, Son NH. Pediatric primary orbital rhabdomyosarcoma. J Pediatr Surg Case Rep. 2020;59:101475. doi:10.1016/j.epsc.2020.101475
Copyright (c) 2024 Arwini Avissa Abdullah, Nadirah Rasyid Ridha
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Once an article was published in the journal, the author(s) are: granted to the journal right licensed under Creative Commons License Attribution that allows others to share the work with an acknowledgement of the work's authorship. permitted to publish their work online in third parties as it can lead wider dissemination of the work. continue to be the copyright owner and allow the journal to publish the article with the CC BY-NC-SA license receiving a DOI (Digital Object Identifier) of the work.