THE ROLE OF p53 AND CASPASE  IN REGULATION APOPTOSIS ACTIVITY

Afrisusnawati Rauf

doi:10.24252/jfuinam.v1i1.2090

Afrisusnawati Rauf Department of Pharmacy, Faculty of Health Science, Islamic State University Alauddin Makassar

DOI: https://doi.org/10.24252/jfuinam.v1i1.2090

Abstract

Apoptosis, or programmed cell death, is a common property of all multicellular organism. Apoptosis occurs normally during development and aging and as a homeostatic mechanism to maintain cell populations in tissue. Apoptosis also accurs as a defense mechanism such as in immune reactions or when cells are damaged by disease or noxious agents. Dysregulation of apoptosis leads to a variety of human pathologies including cancer, autoimmune disease, and neurodegenerative disorders.

References

Benchimol, S. 2001. p53-dependent Pathways of Apoptosis. Cell Death and Differentiation. Vol. 8 : 1049-1051.

Bensaad, K. 2007. p53: New Roles in Metabolism. TRENDS in Cell Biology. Vol. 17(6) : 286-291.

Duprez, L. Wirawan, E. 2009. Major Cell Death Pathways at A Glance. Microbes and Infection. Vol. 11: 1050-1062.

Elmore, S. 2007. Apoptosis : A Review of Programmed Cell Death. Toxicologic Pathology. Vol. 35 : 495-516.

Lavrik, I. Golks, A. 2005. Caspases : Pharmacological Manipulation of Cell Death. The Journal of Clinical Investigation. Vol. 115 : 2665-2672.

Lowe, S. 2004. Intrinsic Tumor Suppression. Nature. Vol. 432 : 307-315.

Macdonald, F. 2004. Molecular Biology of Cancer. Taylor and Francis. United Kingdom.

Melino, G. Vaux, D. 2010. Cell Death. Wiley-Blackwell. United Kingdom.

Riedl, S. 2004. Molecular Mechanism of Caspase Regulation During Apoptosis. Molecular Cell Biology. Vol. 5 : 897-907.

.Rastogi, R. Richa. 2009. Apoptosis :Molecular Mechanisms and Pathogenicity. EXCLI Journal. Vol. 8 : 155-181.

. Robertson, J. 2000. Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemical. Critical Reviews in Toxicology. Vol. 30(5) : 609-627.

. Rozan, LM. 2007. p53 Downstream Targer Genes and Tumor Suppression : A Classical View in Evolution. Cell Death and Differentiation. Vol. 14 : 3-9.

. Sluyser, M. 2005. Application of Apoptosis to Cancer Treatment. Springer. Netherlands.

. Soussi, T. 2007. Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm. Cancer Cell. Vol.